Modulation of sarcoplasmic reticulum Ca2+ cycling in systolic and diastolic heart failure associated with aging
| Autor: | Edward G. Lakatta, Andrzej M. Janczewski |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Aging medicine.medical_specialty Contraction (grammar) Article Sarcoplasmic Reticulum Calcium-Transporting ATPases Sex Factors Risk Factors Stress Physiological Internal medicine Receptors Adrenergic beta medicine Humans Receptor Aged Aged 80 and over chemistry.chemical_classification Heart Failure Diastolic Muscle Cells Reactive oxygen species business.industry Endoplasmic reticulum Cardiac myocyte Age Factors Diastolic heart failure Prognosis medicine.disease Adaptation Physiological United States Sarcoplasmic Reticulum Endocrinology chemistry Heart failure Disease Progression Cardiology Female Cardiology and Cardiovascular Medicine business Intracellular Heart Failure Systolic Signal Transduction |
| Zdroj: | Heart Failure Reviews. 15:431-445 |
| ISSN: | 1573-7322 1382-4147 |
| Popis: | Hypertension, atherosclerosis, and resultant chronic heart failure (HF) reach epidemic proportions among older persons, and the clinical manifestations and the prognoses of these worsen with increasing age. Thus, age per se is the major risk factor for cardiovascular disease. Changes in cardiac cell phenotype that occur with normal aging, as well as in HF associated with aging, include deficits in ss-adrenergic receptor (ss-AR) signaling, increased generation of reactive oxygen species (ROS), and altered excitation-contraction (EC) coupling that involves prolongation of the action potential (AP), intracellular Ca(2+) (Ca(i)(2+)) transient and contraction, and blunted force- and relaxation-frequency responses. Evidence suggests that altered sarcoplasmic reticulum (SR) Ca(2+) uptake, storage, and release play central role in these changes, which also involve sarcolemmal L-type Ca(2+) channel (LCC), Na(+)-Ca(2+) exchanger (NCX), and K(+) channels. We review the age-associated changes in the expression and function of Ca(2+) transporting proteins, and functional consequences of these changes at the cardiac myocyte and organ levels. We also review sexual dimorphism and self-renewal of the heart in the context of cardiac aging and HF. |
| Databáze: | OpenAIRE |
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