Stomal adenocarcinoma in Crohn's disease
Autor: | D J Sherlock, V Suarez, J G Gray |
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Rok vydání: | 1990 |
Předmět: |
Male
Pathology medicine.medical_specialty Epithelial dysplasia Time Factors medicine.medical_treatment Cecal Neoplasms Adenocarcinoma Malignancy Gastroenterology Ileostomy Crohn Disease Internal medicine Intestinal Neoplasms medicine Carcinoma Humans Crohn's disease business.industry Enterostomy Middle Aged medicine.disease Ulcerative colitis digestive system diseases Ileal Neoplasms Cecostomy Dysplasia Female business Research Article |
Zdroj: | Gut. 31:1329-1332 |
ISSN: | 0017-5749 |
DOI: | 10.1136/gut.31.11.1329 |
Popis: | Malignant change occurring at the site of a stoma in two patients with proved Crohn's disease is described. Patients with ulcerative colitis have an increased risk of colonic malignancy and Crohn's disease is also associated with both small and large bowel carcinoma. Most previous reports of stomal carcinoma have been associated with ulcerative colitis although Crohn's disease seems to carry a greater risk of associated small bowel carcinomas. This is the first report of stomal carcinoma complicating Crohn's disease. Epithelial dysplasia is associated with gastrointestinal carcinomas in both ulcerative colitis and Crohn's disease and a dysplasia-carcinoma sequence has been suggested as the origin of these tumours. In both our patients with stomal adenocarcinoma, dysplasia was identified in adjacent tissues, which suggests a similar mechanism. Malignant change should be suspected if epithelial dysplasia is discovered in a biopsy specimen from the mucosa of an ileostomy in Crohn's disease, and this risk is increased if the dysplasia is of a high grade. |
Databáze: | OpenAIRE |
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