Effect of nitric oxide blockade on the lower limit of the cortical cerebral autoregulation in pentobarbital-anaesthetized rats
| Autor: | G. Leftheriotis, V. Banssillon, C.S. Degoute, J.L. Saumet, M.P. Preckel, C. Ferber |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Pentobarbital Mean arterial pressure Physiology medicine.medical_treatment Drug Evaluation Preclinical Blood Pressure Nitric Oxide Cerebral autoregulation Nitroarginine Nitric oxide chemistry.chemical_compound Phenylephrine medicine Animals Homeostasis Enzyme Inhibitors Rats Wistar Saline Anesthetics Cerebral Cortex Laser Doppler velocimetry Rats chemistry Cerebral blood flow Anesthesia Cerebrovascular Circulation Vascular Resistance Nitric Oxide Synthase Cardiology and Cardiovascular Medicine medicine.drug |
| Zdroj: | International journal of microcirculation, clinical and experimental. 16(6) |
| ISSN: | 0167-6865 |
| Popis: | The role of nitric oxide (NO) in cerebral autoregulation is controversial. The purpose of this study was to compare the effects on the lower limit of the cortical cerebral autoregulation of the inhibition of NO synthesis by N omega-nitro-L-arginine (L-NNA) infusion to saline and phenylephrine in pentobarbital-anaesthetized rats. Variations of the cortical cerebral blood flow (CBF), the cortical cerebrovascular resistances, the mean arterial pressure and the lower limit of cerebral autoregulation were compared in three groups: a group pretreated with L-NNA (n = 8), a group pretreated with saline (n = 8) and a group pretreated with phenylephrine (n = 5). The laser-Doppler flowmetry continuously measured CBF. Controlled haemorrhage was performed after the intravenous infusion of L-NNA, saline, or phenylephrine. The lower limit of cerebral autoregulation of each rat was computed by the least-squares method. The lower limit of cerebral autoregulation was significantly higher after L-NNA infusion (74 +/- 5 mm Hg) than after saline (43 +/- 3 mm Hg; p0.01) or phenylephrine infusions (52 +/- 5 mm Hg; p0.05). In conclusion, the role of NO on the cerebral autoregulation has been controversial; our results confirm the hypothesis that NO exerts a significant role in maintaining the lower limit of cerebral autoregulation in pentobarbital-anaesthetized rats. |
| Databáze: | OpenAIRE |
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