The dilution effect limits plasmid horizontal transmission in multispecies bacterial communities
| Autor: | Anastasia Kottara, James P. J. Hall, Laura Carrilero, Michael A. Brockhurst, Ellie Harrison |
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| Rok vydání: | 2021 |
| Předmět: |
Infection risk
Gene Transfer Horizontal Biology Microbiology 03 medical and health sciences Plasmid experimental evolution plasmid transfer 030304 developmental biology Genetics 0303 health sciences Experimental evolution Bacteria conjugative plasmids 030306 microbiology Host (biology) Microbial Interactions and Communities mobile genetic elements bacterial communities Dilution Conjugation Genetic Horizontal gene transfer horizontal gene transfer Mobile genetic elements human activities Horizontal transmission Plasmids |
| Zdroj: | Microbiology Kottara, A, Carrilero, L, Harrison, E, Hall, J P J & Brockhurst, M A 2021, ' The dilution effect limits plasmid horizontal transmission in multispecies bacterial communities ', Microbiology, vol. 167, no. 9 . https://doi.org/10.1099/mic.0.001086 Microbiology (Reading, England) |
| ISSN: | 1465-2080 1350-0872 |
| Popis: | By transferring ecologically important traits between species, plasmids drive genomic divergence and evolutionary innovation in their bacterial hosts. Bacterial communities are often diverse and contain multiple coexisting plasmids, but the dynamics of plasmids in multispecies communities are poorly understood. Here, we show, using experimental multispecies communities containing two plasmids, that bacterial diversity limits the horizontal transmission of plasmids due to ‘the dilution effect’; an epidemiological phenomenon whereby living alongside less proficient host species reduces the expected infection risk for a focal host species. In addition, plasmid horizontal transmission was also affected by plasmid diversity, such that the rate of plasmid conjugation was reduced from coinfected host cells carrying both plasmids. In diverse microbial communities, plasmid spread may be limited by the dilution effect and plasmid-plasmid interactions reducing the rate of horizontal transmission. |
| Databáze: | OpenAIRE |
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