Advances in polysaccharide nanocrystals as pharmaceutical excipients
| Autor: | Huize Luo, Yanxue Si, Lu Han, Ruitao Cha, Xinyi Bai, Fengshan Zhou, Huimin Sun |
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| Rok vydání: | 2020 |
| Předmět: |
animal structures
Polymers and Plastics Biocompatibility Nanotechnology Biocompatible Materials Chitin 02 engineering and technology 010402 general chemistry Polysaccharide 01 natural sciences Nanocomposites Excipients chemistry.chemical_compound Polysaccharides Materials Chemistry Humans Thermal stability Cellulose chemistry.chemical_classification Active ingredient Organic Chemistry Hydrogels Starch 021001 nanoscience & nanotechnology 0104 chemical sciences High surface Cellulose nanocrystals Drug Liberation nervous system chemistry Nanocrystal Solubility Nanoparticles sense organs Adsorption 0210 nano-technology |
| Zdroj: | Carbohydrate polymers. 262 |
| ISSN: | 1879-1344 |
| Popis: | Polysaccharide nanocrystals (PNs) are attractive pharmaceutical excipients due to their abundant surface hydroxyl groups, high surface charges, prominent mechanical properties, excellent fluidity, and good swelling properties. In this review, we summarize three kinds of PNs, including cellulose nanocrystals (CNCs), starch nanocrystals (SNCs), and chitin nanocrystals (ChNCs). We introduce the applications of PNs as stabilizers, adsorbents, film-forming materials, gel materials, disintegrants, and ointment matrices. We focus on the advantages of PNs to improve mechanical properties, thermal stability, therapeutic effect, biocompatibility, and release of active pharmaceutical ingredients. We discuss regulatory issues of PNs. We finally propose the challenges and future perspectives of PNs as pharmaceutical excipients. |
| Databáze: | OpenAIRE |
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