Describing the Prevalence of Neural Tube Defects Worldwide: A Systematic Literature Review

Autor: Michael J. Cannon, Jorge Rosenthal, Jennifer Williams, Ahlia Sekkarie, Becky L. Tsang, Joseph Mulinare, Hilda Razzaghi, Ibrahim Zaganjor, Joseph E. Sniezek
Rok vydání: 2015
Předmět:
Spina Bifida
B Vitamins
Pediatrics
lcsh:Medicine
Global Health
Geographical Locations
Database and Informatics Methods
0302 clinical medicine
Global health
Prevalence
Medicine and Health Sciences
Morphogenesis
Public and Occupational Health
030212 general & internal medicine
Neural Tube Defects
Database Searching
lcsh:Science
Multidisciplinary
Organic Compounds
Vitamins
Research Assessment
Chemistry
medicine.anatomical_structure
Systematic review
Neurology
Physical Sciences
Research Article
congenital
hereditary
and neonatal diseases and abnormalities
medicine.medical_specialty
China
Asia
Systematic Reviews
Research and Analysis Methods
Spinal Cord Diseases
03 medical and health sciences
Folic Acid
medicine
Congenital Disorders
Humans
Birth Defects
Intensive care medicine
business.industry
lcsh:R
Organic Chemistry
Neural tube
Chemical Compounds
Biology and Life Sciences
Folic acid
People and Places
lcsh:Q
business
030217 neurology & neurosurgery
Developmental Biology
Zdroj: PLoS ONE
PLoS ONE, Vol 11, Iss 4, p e0151586 (2016)
ISSN: 1932-6203
Popis: BACKGROUND:Folate-sensitive neural tube defects (NTDs) are an important, preventable cause of morbidity and mortality worldwide. There is a need to describe the current global burden of NTDs and identify gaps in available NTD data. METHODS AND FINDINGS:We conducted a systematic review and searched multiple databases for NTD prevalence estimates and abstracted data from peer-reviewed literature, birth defects surveillance registries, and reports published between January 1990 and July 2014 that had greater than 5,000 births and were not solely based on mortality data. We classified countries according to World Health Organization (WHO) regions and World Bank income classifications. The initial search yielded 11,614 results; after systematic review we identified 160 full text manuscripts and reports that met the inclusion criteria. Data came from 75 countries. Coverage by WHO region varied in completeness (i.e., % of countries reporting) as follows: African (17%), Eastern Mediterranean (57%), European (49%), Americas (43%), South-East Asian (36%), and Western Pacific (33%). The reported NTD prevalence ranges and medians for each region were: African (5.2-75.4; 11.7 per 10,000 births), Eastern Mediterranean (2.1-124.1; 21.9 per 10,000 births), European (1.3-35.9; 9.0 per 10,000 births), Americas (3.3-27.9; 11.5 per 10,000 births), South-East Asian (1.9-66.2; 15.8 per 10,000 births), and Western Pacific (0.3-199.4; 6.9 per 10,000 births). The presence of a registry or surveillance system for NTDs increased with country income level: low income (0%), lower-middle income (25%), upper-middle income (70%), and high income (91%). CONCLUSIONS:Many WHO member states (120/194) did not have any data on NTD prevalence. Where data are collected, prevalence estimates vary widely. These findings highlight the need for greater NTD surveillance efforts, especially in lower-income countries. NTDs are an important public health problem that can be prevented with folic acid supplementation and fortification of staple foods.
Databáze: OpenAIRE
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