Use of high doses of folic acid supplements in pregnant women in Spain: an INMA cohort study

Autor: Adonina Tardon, LORETO SANTA MARINA, Manuela Garcia de la Hera, DANIEL GIMENEZ-MONZO, Isolina Riaño-Galan, Jesus Ibarluzea, Marisa Rebagliato, Joan Forns, Eva María Navarrete-Muñoz, MIKEL BASTERRECHEA, Mario Murcia, Francisco Artacho-Cordon, Jordi Julvez, Eva Morales, Ibon Tamayo Uria, Carmen Iñiguez, Sandra González Palacios, Ana Fernández Somoano, Nicolas Olea, Jesus Vioque
Jazyk: angličtina
Rok vydání: 2015
Předmět:
consumo de alcohol
modelos logísticos
embarazo
humanos
ácido fólico
adolescente
Abortion
Pregnancy
estudios prospectivos
Odds Ratio
Medicine
fenómenos fisiológicos nutricionales maternos
Prospective Studies
Prospective cohort study
education.field_of_study
Obstetrics
Smoking
public health
Pregnancy
Unplanned
Prenatal Care
General Medicine
adulto
cociente de probabilidades relativas
adulto joven
Parity
Female
PUBLIC HEALTH
paridad
Cohort study
Adult
medicine.medical_specialty
asistencia prenatal
Adolescent
Alcohol Drinking
Population
NUTRITION & DIETETICS
Prenatal care
Young Adult
Folic Acid
Humans
education
nutrition & dietetics
business.industry
Research
Odds ratio
Maternal Nutritional Physiological Phenomena
hábito de fumar
medicine.disease
Surgery
Abortion
Spontaneous
Logistic Models
Reproductive Medicine
Spain
Relative risk
Dietary Supplements
business
Zdroj: WOS:000368840100120
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Repositori Universitat Jaume I
Universitat Jaume I
BMJ Open
Popis: Objectives: We examined the use of low (= 1000 mu g/day) among pregnant women in Spain, and explored factors associated with the use of these non-recommended dosages. Design: Population-based cohort study. Setting: Spain. Participants: We analysed data from 2332 pregnant women of the INMA study, a prospective mother-child cohort study in Spain. Main outcome measures: We assessed usual dietary folate and the use of FAS from preconception to the 3rd month (first period) and from the 4th to the 7th month (second period), using a validated food frequency questionnaire. We used multinomial logistic regression to estimate relative risk ratios (RRRs). Results: Over a half of the women used low dosages of FAS in the first and second period while 29% and 17% took high dosages of FAS, respectively. In the first period, tobacco smoking (RRR=1.63), alcohol intake (RRR=1.40), multiparous (RRR=1.44), unplanned pregnancy (RRR=4.20) and previous spontaneous abortion (RRR=0.58, lower use of high FAS dosages among those with previous abortions) were significantly associated with low FAS dosages. Alcohol consumption (RRR=1.42), unplanned pregnancy (RRR=2.66) and previous spontaneous abortion (RRR=0.68) were associated with high dosage use. In the second period, only tobacco smoking was significantly associated with high FAS dosage use (RRR=0.67). Conclusions: A high proportion of pregnant women did not reach the recommended dosages of FAS in periconception and a considerable proportion also used FAS dosages >= 1000 mu g/day. Action should be planned by the Health Care System and health professionals to improve the appropriate periconceptional use of FAS, taking into consideration the associated factors.
This study was funded by grants from Instituto de Salud Carlos III and Spanish Ministry of Health (Red INMA G03/176; CB06/02/0041; FIS 97/0588; 00/0021-2, PI061756; PS0901958; FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314; 09/02647; FIS-PI041436, FIS-PI081151, FIS-PI06/0867; FIS-PS09/00090, FIS-PI042018, FIS-PI09 02311, FIS PI11/01007, FISPI13/02429) Universidad de Oviedo, Conselleria de Sanitat Generalitat Valenciana, Generalitat de Catalunya-CIRIT 1999SGR 00241, Department of Health of the Basque Government (2005111093 and 2009111069) and the Provincial Government of Guipuzcoa (DFG06/004 and DFG08/001).
Databáze: OpenAIRE
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