Dietary Chitosan Nanoparticles: Potential Role in Modulation of Rainbow Trout (Oncorhynchus mykiss) Antibacterial Defense and Intestinal Immunity against Enteric Redmouth Disease

Autor: Faiza M. Soliman, Mansour El-Matbouli, Mohamed A. Adly, Fatma Ahmed, Hamdy A.M. Soliman, Mona Saleh
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Yersinia ruckeri
Blood Bactericidal Activity
chitosan nanoparticles
Pharmaceutical Science
intestinal immunity
Article
Microbiology
Commercial fish feed
03 medical and health sciences
skin mucus
Fish Diseases
prophylactic-regimen
Drug Discovery
Animals
Immunologic Factors
lcsh:QH301-705.5
Pharmacology
Toxicology and Pharmaceutics (miscellaneous)
therapeutic-regimen
030304 developmental biology
0303 health sciences
Chitosan
biology
Enteric redmouth disease
04 agricultural and veterinary sciences
biology.organism_classification
Antimicrobial
Mucus
rainbow trout
Anti-Bacterial Agents
antibacterial defense
Intestines
Trout
lcsh:Biology (General)
ERM
Oncorhynchus mykiss
Dietary Supplements
040102 fisheries
0401 agriculture
forestry
and fisheries
Nanoparticles
Rainbow trout
Antibacterial activity
serum
Zdroj: Marine Drugs
Volume 19
Issue 2
Marine Drugs, Vol 19, Iss 72, p 72 (2021)
ISSN: 1660-3397
Popis: Bio-nanotechnology employing bio-sourced nanomaterial is an emerging avenue serving the field of fish medicine. Marine-sourced chitosan nanoparticles (CSNPs) is a well-known antimicrobial and immunomodulatory reagent with low or no harm side effects on fish or their human consumers. In this study, in vitro skin mucus and serum antibacterial activity assays along with intestinal histology, histochemical, and gene expression analyses were performed to evaluate the impact of dietary CSNPs (5 g kg−1 dry feed) on rainbow trout resistance against ‘enteric redmouth’ disease. Two treatment conditions were included
short-term prophylactic-regimen for 21 days before the bacterial challenge, and long-term therapeutic-regimen for 21 days before the challenge and extended for 28 days after the challenge. Our results revealed higher antibacterial defense ability and positive intestinal histochemical and molecular traits of rainbow trout after dietary CSNPs. The prophylactic-regimen improved trout health while the therapeutic regimen improved their disease resistance and lowered their morbidity. Therefore, it is anticipated that CSNPs is an effective antibacterial and immunomodulatory fish feed supplement against the infectious threats. However, the CSNPs seem to be more effective in the therapeutic application rather than being used for short-term prophylactic applications.
Databáze: OpenAIRE
Externí odkaz: