Perivascular vital cells in the ablation center after multibipolar radiofrequency ablation in an in vivo porcine model
| Autor: | Poch, F. G. M., Neizert, C. A., Geyer, B., Gemeinhardt, O., Niehues, S. M., Vahldiek, J. L., Bressem, K. K., Lehmann, K. S. |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Radiofrequency Ablation
Swine Science Liver Neoplasms Multibipolar radiofrequency ablation (RFA) Article Gastrointestinal cancer Disease Models Animal Medical research Oncology Liver cardiovascular system Animals Medicine Perivascular vital cells in vivo porcine model 600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) Scientific Reports |
| Popis: | Multibipolar radiofrequency ablation (RFA) is an advanced ablation technique for early stage hepatocellular carcinoma and liver metastases. Vessel cooling in multibipolar RFA has not been systematically investigated. The objective of this study was to evaluate the presence of perivascular vital cells within the ablation zone after multibipolar RFA. Multibipolar RFA were performed in domestic pigs in vivo. Three internally cooled bipolar RFA applicators were used simultaneously. Three experimental settings were planned: (1) inter-applicator-distance: 15 mm; (2) inter-applicator-distance: 20 mm; (3) inter-applicator-distance: 20 mm with hepatic inflow occlusion (Pringle maneuver). A vitality staining was used to analyze liver cell vitality around all vessels in the ablation center with a diameter > 0.5 mm histologically. 771 vessels were identified. No vital tissue was seen around 423 out of 429 vessels (98.6%) situated within the central white zone. Vital cells could be observed around major hepatic vessels situated adjacent to the ablation center. Vessel diameter (> 3.0 mm; p |
| Databáze: | OpenAIRE |
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