Extracts from the Leaves of Cissus verticillata Ameliorate High-Fat Diet-Induced Memory Deficits in Mice
| Autor: | Soon Sung Lim, Woosuk Kim, Dong-Sool Yu, Soo Young Choi, Beom Goo Kang, Hyun Jung Kwon, In Koo Hwang, Dae Won Kim, Yong-Bok Jo, Hyo Young Jung |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
obesity
medicine.medical_specialty Plant Science Glucagon Article chemistry.chemical_compound novel object recognition Lipid droplet Internal medicine medicine Hippocampus (mythology) Ecology Evolution Behavior and Systematics Cissus verticillata Brain-derived neurotrophic factor Ecology Triglyceride biology medicine.diagnostic_test business.industry brain-derived neurotrophic factor digestive oral and skin physiology Botany nutritional and metabolic diseases food and beverages medicine.disease biology.organism_classification Obesity lipid profile neurogenesis Endocrinology chemistry QK1-989 lipids (amino acids peptides and proteins) Lipid profile business |
| Zdroj: | Plants Volume 10 Issue 9 Plants, Vol 10, Iss 1814, p 1814 (2021) |
| ISSN: | 2223-7747 |
| DOI: | 10.3390/plants10091814 |
| Popis: | We investigated the effects of Cissus verticillata leaf extract (CVE) on a high-fat diet (HFD)-induced obesity and memory deficits. Male mice (5 weeks of age) were fed vehicle (distilled water), or 30, 100, or 300 mg/kg of CVE once a day for 8 weeks with an HFD. Treatment with CVE resulted in lower body weight and glucose levels in a concentration- and feeding time-dependent manner. LDL cholesterol and triglyceride levels were significantly lower in the CVE-treated HFD group than in the vehicle-treated HFD group. In contrast, high-density lipoprotein cholesterol levels did not show any significant changes. Lipid droplets and ballooning were reduced depending on the concentration of CVE treatment compared to the HFD group. Treatment with CVE ameliorated the increase in glucagon and immunoreactivities in the pancreas, and novel object recognition memory was improved by 300 mg/kg CVE treatment compared to the HFD group. More proliferating cells and differentiated neuroblasts were higher in mice treated with CVE than in vehicle-treated HFD-fed mice. Brain-derived neurotrophic factor (BDNF) levels were significantly decreased in the HFD group, which was facilitated by treatment with 300 mg/kg CVE in hippocampal homogenates. These results suggest that CVE ameliorates HFD-induced obesity and memory deficits in mice, associated with increased BDNF levels in the hippocampus. |
| Databáze: | OpenAIRE |
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