Measurement of Brain Metabolites in Patients with type 2 Diabetes and Major Depression Using Proton Magnetic Resonance Spectroscopy
| Autor: | Jacqueline Miller, Nader Binesh, Olusola Ajilore, S. Senthil Kumaran, Jim Mintz, Christine Darwin, Anand Kumar, M. Albert Thomas, Ebrahim Haroon |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Magnetic Resonance Spectroscopy Glutamine Glutamic Acid Prefrontal Cortex Type 2 diabetes Creatine Choline Diabetes Complications White matter chemistry.chemical_compound Internal medicine Diabetes mellitus medicine Humans Depression (differential diagnoses) Aged Aged 80 and over Brain Chemistry Psychiatric Status Rating Scales Pharmacology Aspartic Acid Depressive Disorder Major Middle Aged medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health B vitamins Endocrinology medicine.anatomical_structure Diabetes Mellitus Type 2 chemistry Mood disorders Female Psychology Inositol |
| Zdroj: | Neuropsychopharmacology. 32:1224-1231 |
| ISSN: | 1740-634X 0893-133X |
| Popis: | Type 2 diabetes and major depression are disorders that are mutual risk factors and may share similar pathophysiological mechanisms. To further understand these shared mechanisms, the purpose of our study was to examine the biochemical basis of depression in patients with type 2 diabetes using proton MRS. Patients with type 2 diabetes and major depression (n=20) were scanned along with patients with diabetes alone (n=24) and healthy controls (n=21) on a 1.5 T MRI/MRS scanner. Voxels were placed bilaterally in dorsolateral white matter and the subcortical nuclei region, both areas important in the circuitry of late-life depression. Absolute values of myo-inositol, creatine, N-acetyl aspartate, glutamate, glutamine, and choline corrected for CSF were measured using the LC-Model algorithm. Glutamine and glutamate concentrations in depressed diabetic patients were significantly lower (p |
| Databáze: | OpenAIRE |
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