Triterpenoids. Part 21: Oleanolic acid azaderivatives as percutaneous transport promoters

Autor:	Lucjusz Zaprutko, Danuta Partyka, Barbara Bednarczyk-Cwynar
Rok vydání:	2004
Předmět:	Lactams Stereochemistry Skin Absorption Clinical Biochemistry Biological Transport Active Pharmaceutical Science In Vitro Techniques Administration Cutaneous Biochemistry Chemical synthesis Permeability Structure-Activity Relationship chemistry.chemical_compound Triterpene Drug Discovery Humans Organic chemistry Molecular Biology Oleanolic acid Progesterone Adjuvants Pharmaceutic chemistry.chemical_classification Aza Compounds Organic Chemistry Membranes Artificial Promoter Triterpenes In vitro Terpenoid chemistry Lactam Molecular Medicine Azone
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 14:4723-4726
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2004.06.087
Popis:	Some new oleanolic acid derivatives with lactame and thiolactame structures in the A- or C-ring were prepared and tested as percutaneous transport promoters in vitro. Their activity was comparable with activity of N-dodecylcaprolactame (Azone). A-Thiolactame derivative of methyl oleanolate (13) was the most effective compound.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79c7190bb1fcda5efd3ffc5fc6551d4 https://doi.org/10.1016/j.bmcl.2004.06.087 Zobrazit plný text záznamu Full Text from ScienceDirect