Clinical Evidence of Effects of Lactobacillus plantarum HY7714 on Skin Aging: A Randomized, Double Blind, Placebo-Controlled Study
| Autor: | Young Kyoung Seo, Dong Eun Lee, Jehyeon Ra, Chul-Sung Huh, Ja Hyun Ryu, Junghee Lee, Sim Jae Hun, Il Dong Choi, Young-Tae Ahn, Jae Sook Koh, Sung Hwan Kim, Ji Woong Jeong |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Placebo-controlled study Placebo Applied Microbiology and Biotechnology Gastroenterology law.invention Skin Aging Placebos Probiotic Double-Blind Method law Skin Physiological Phenomena Internal medicine Dry skin medicine Humans Wrinkle Transepidermal water loss integumentary system business.industry Probiotics General Medicine Middle Aged Treatment Outcome Female medicine.symptom business Lactobacillus plantarum Biotechnology |
| Zdroj: | Journal of Microbiology and Biotechnology. 25:2160-2168 |
| ISSN: | 1738-8872 1017-7825 |
| DOI: | 10.4014/jmb.1509.09021 |
| Popis: | The beneficial effects of probiotics are now widely reported, although there are only a few studies on their anti-aging effects. We have found that Lactobacillus plantarum HY7714 (HY7714) improves skin hydration and has anti-photoaging effects, and in the present study, we have further evaluated the anti-aging effect of HY7714 via a randomized, double blind, placebo-controlled clinical trial. The trial included 110 volunteers aged 41 and 59 years who have dry skin and wrinkles. Participants took 1 × 10(10) CFU/day of HY7714 (probiotic group) or a placebo (placebo group) for 12 weeks. Skin hydration, wrinkles, skin gloss, and skin elasticity were measured every 4 weeks during the study period. There were significant increases in the skin water content in the face (p < 0.01) and hands (p < 0.05) at week 12 in the probiotic group. Transepidermal water loss decreased significantly in both groups at weeks 4, 8, and 12 (p < 0.001 compared with baseline), and was suppressed to a greater extent in the face and forearm in the probiotic group at week 12. Volunteers in the probiotic group had a significant reduction in wrinkle depth at week 12, and skin gloss was also significantly improved by week 12. Finally, skin elasticity in the probiotic group improved by 13.17% (p < 0.05 vs. controls) after 4 weeks and by 21.73% (p < 0.01 vs. controls) after 12 weeks. These findings are preliminary confirmation of the anti-aging benefit to the skin of L. plantarum HY7714 as a nutricosmetic agent. |
| Databáze: | OpenAIRE |
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