The SURF (Italian observational study for renal insufficiency evaluation in liver transplant recipients): A post-hoc between-sex analysis
| Autor: | Colombo D., Zagni E., Zullo A., Simoni L., Fagiuoli S., De Simone P., Donati D., Salizzoni M., Angeli P., Burra P., Cillo U., Toniutto P., Rossi M., Vennarecci G., De Carlis L., Donato F., Cescon M., Di Leo A., Di Costanzo G. G., Avolio A. |
|---|---|
| Přispěvatelé: | Colombo D., Zagni E., Zullo A., Simoni L., Fagiuoli S., De Simone P., Donati D., Salizzoni M., Angeli P., Burra P., Cillo U., Toniutto P., Rossi M., Vennarecci G., De Carlis L., Donato F., Cescon M., Di Leo A., Di Costanzo G.G., Avolio A., Colombo, D, Zagni, E, Zullo, A, Simoni, L, Fagiuoli, S, De Simone, P, Donati, D, Salizzoni, M, Angeli, P, Burra, P, Cillo, U, Toniutto, P, Rossi, M, Vennarecci, G, De Carlis, L, Donato, F, Cescon, M, Di Leo, A, Di Costanzo, G, Avolio, A |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Nephrology
Adult Male medicine.medical_specialty Settore MED/18 - CHIRURGIA GENERALE Renal function lcsh:RC870-923 03 medical and health sciences 0302 clinical medicine Calcineurin inhibitors Calcineurin inhibitor Internal medicine Sex differences Medicine Humans Meta-analysi 030212 general & internal medicine Longitudinal Studies Renal insufficiency Liver transplant Aged Retrospective Studies Sex Characteristics business.industry Gender Middle Aged medicine.disease lcsh:Diseases of the genitourinary system. Urology Transplant Recipients Liver Transplantation Calcineurin Transplantation Meta-analysis Clinical research Cross-Sectional Studies Italy 030211 gastroenterology & hepatology Observational study Female business Research Article Kidney disease Follow-Up Studies Glomerular Filtration Rate |
| Zdroj: | BMC Nephrology, Vol 20, Iss 1, Pp 1-10 (2019) BMC Nephrology |
| Popis: | Background Female sex has been reported as an independent predictor of severe post-liver transplantation (LT) chronic kidney disease. We performed a by sex post-hoc analysis of the SURF study, that investigated the prevalence of renal impairment following LT, aimed at exploring possible differences between sexes in the prevalence and course of post-LT renal damage. Methods All patients enrolled in the SURF study were considered evaluable for this sex-based analysis, whose primary objective was to evaluate by sex the proportion of patients with estimated Glomerular Filtration Rate (eGFR) 2 at inclusion and follow-up visit. Results Seven hundred thirty-eight patients were included in our analysis, 76% males. The proportion of patients with eGFR 2 was significantly higher in females at initial study visit (33.3 vs 22.8%; p = 0.005), but also before, at time of transplantation (22.9 vs 14.7%; p = 0.0159), as analyzed retrospectively. At follow-up, such proportion increased more in males than in females (33.9 vs 26.0%, p = 0.04). Mean eGFR values decreased over the study in both sexes, with no significant differences. Statistically significant M/F differences in patient distribution by O’Riordan eGFR levels were observed at time of transplant and study initial visit (p = 0.0005 and 0.0299 respectively), but not at follow-up. Conclusions Though the limitation of being performed post-hoc, this analysis suggests potential sex differences in the prevalence of renal impairment before and after LT, encouraging further clinical research to explore such differences more in depth. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|