WMHs AND HOMOCYSTEINE LEVELS AS CANDIDATE BIOMARKER FOR COGNITIVE IMPAIRMENT
| Autor: | Nagarajan K, Kuppan J, Ennapadam S. Krishnamoorthy, Misra, Balaji S |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty business.industry Homocysteine levels medicine.disease 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Internal medicine Plasma homocysteine medicine Biomarker (medicine) Dementia Cognitive impairment business Inverse correlation 030217 neurology & neurosurgery Depression (differential diagnoses) Biochemical markers |
| DOI: | 10.1101/2020.05.04.20090704 |
| Popis: | The aim of this pilot study was to test the hypotheses that a) WMHs would be a biological marker in South Indian patients who present with either cognitive impairment, dementia or depression and b) presence of WMHs would be related to other blood biochemical markers. A significant positive correlation was present between temporal WMHs and increased homocysteine levels. A significant inverse correlation was obtained between MMSE scores and frontal caps. Association between temporal WMHs and elevated plasma homocysteine levels implies that this can serve as a biological marker for cognitive impairment and possibly for therapy. |
| Databáze: | OpenAIRE |
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