Theta-phase closed-loop stimulation induces motor paradoxical responses in the rat model of Parkinson disease
| Autor: | Sandra Arrieta, Ivan Cordon, Manuel Alegre, Miguel Valencia, María Jesús Nicolás, Julio Artieda |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Deep brain stimulation medicine.medical_treatment Rat model Biophysics Stimulation Disease Motor deficit lcsh:RC321-571 03 medical and health sciences 0302 clinical medicine Parkinsonian Disorders medicine Animals Rats Wistar Theta Rhythm Beta (finance) lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Rat model of Parkinson's disease business.industry General Neuroscience Motor Cortex Parkinson Disease Neurophysiology Rats Disease Models Animal 030104 developmental biology medicine.anatomical_structure Motor Skills Neurology (clinical) Close/open-loop scheme Neurophysiological correlate of behavior business Motor Deficit Neuroscience Locomotion 030217 neurology & neurosurgery Motor cortex |
| Zdroj: | Brain Stimulation, Vol 11, Iss 1, Pp 231-238 (2018) |
| ISSN: | 1935-861X |
| Popis: | Background High-frequency deep brain stimulation (DBS) has become a widespread therapy used in the treatment of Parkinson's Disease (PD) and other diseases. Although it has proved beneficial, much recent attention has been centered around the potential of new closed-loop DBS implementations. Objective Here we present a new closed-loop DBS scheme based on the phase of the theta activity recorded from the motor cortex. By testing the implementation on freely moving 6-OHDA lesioned and control rats, we assessed the behavioral and neurophysiologic effects of this implementation and compared it against the classical high-frequency DBS. Results Results show that both stimulation modalities produce significant and opposite changes on the movement and neurophysiological activity. Close-loop stimulation, far from improving the animals' behavior, exert contrary effects to those of high-frequency DBS which reverts the parkinsonian symptoms. Motor improvement during open-loop, high-frequency DBS was accompanied by a reduction in the amount of cortical beta oscillations while akinetic and disturbed behavior during close-loop stimulation coincided with an increase in the amplitude of beta activity. Conclusion Cortical-phase-dependent close-loop stimulation of the STN exerts significant behavioral and oscillatory changes in the rat model of PD. Open-loop and close-loop stimulation outcomes differed dramatically, thus suggesting that the scheme of stimulation determines the output of the modulation even if the target structure is maintained. The current framework could be extended in future studies to identify the correct parameters that would provide a suitable control signal to the system. It may well be that with other stimulation parameters, this sort of DBS could be beneficial. |
| Databáze: | OpenAIRE |
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