In Phantom Validation of Time-Domain Near-Infrared Optical Tomography Pioneer for Imaging Brain Hypoxia and Hemorrhage
| Autor: | Edoardo Charbon, Martin Wolf, A. Di Costanzo-Mata, Jingjing Jiang, Alexander Kalyanov, Chao Zhang, Scott Lindner |
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| Přispěvatelé: | University of Zurich, Nemoto, Edwin M, Kalyanov, A |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
reconstruction Tissue oxygenation Preterm brain imaging Ischemia 610 Medicine & health Imaging brain Imaging phantom Time 03 medical and health sciences 0302 clinical medicine 1300 General Biochemistry Genetics and Molecular Biology preterm brain imaging Medicine tissue oxygenation 030212 general & internal medicine Time domain Optical tomography time-domain near-infrared optical tomography (td nitor) medicine.diagnostic_test business.industry Near-infrared spectroscopy infrared optical tomography (TD NITOR) domain near Tissue optical properties reconstruction Hypoxia (medical) medicine.disease 10027 Clinic for Neonatology Diffuse optical imaging Diffuse optical tomography Radiology medicine.symptom business preterm |
| Zdroj: | Advances in Experimental Medicine and Biology ISBN: 9783030482367 |
| DOI: | 10.5167/uzh-212620 |
| Popis: | The neonatal brain is a vulnerable organ, and lesions due to hemorrhage and/or ischemia occur frequently in preterm neonates. Even though neuroprotective therapies exist, there is no tool available to detect the ischemic lesions. To address this problem, we have recently designed and built the new time-domain near-infrared optical tomography (TD NIROT) system – Pioneer. Here we present the results of a phantom study of the system performance. We used silicone phantoms to mimic risky situations for brain lesions: hemorrhage and hypoxia. Employing Pioneer, we were able to reconstruct accurately both position and optical properties of these inhomogeneities. |
| Databáze: | OpenAIRE |
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