Influence of starvation on the dihydrotestosterone-luteinizing hormone feedback in the male rat
| Autor: | Jose Lino Baraño, Ricardo S. Calandra, Barbara Spyra, Isabel Alicia Luthy, Karl M. Pirke |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
medicine.medical_specialty Biology Biochemistry Feedback chemistry.chemical_compound Endocrinology Internal medicine medicine Animals Testosterone Castration Drug Implants Starvation Lh secretion Dihydrotestosterone Rats Inbred Strains Plasma levels Luteinizing Hormone Silastic Rats chemistry medicine.symptom Luteinizing hormone Half-Life medicine.drug |
| Zdroj: | Journal of Steroid Biochemistry. 16:403-406 |
| ISSN: | 0022-4731 |
| DOI: | 10.1016/0022-4731(82)90052-8 |
| Popis: | The suppressing effect of dihydrotestosterone (DHT) on LH secretion in freshly castrated starved and control rats was studied by implanting DHT releasing silastic capsules of various sizes. Lower plasma levels of DHT are needed to suppress the castration induced LH increase in the starved animals. Intravenous injection of tritiated testosterone (18 muCi/100 g b.wt) revealed a significantly longer half-life (12.4 vs 8.9; P less than 0.05) in the starved rat. The ratio [3H]-DHT/[3H]-T in plasma at various times after injection was not significantly different in starved and control animals. The results indicate that the increased sensitivity of the T-LH feedback report earlier [1] cannot be explained by a greater conversion T-DHT in the starved male rat. |
| Databáze: | OpenAIRE |
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