Azole susceptibility and resistance in Candida dubliniensis
| Autor: | Gary P. Moran, Derek J. Sullivan, David C. Coleman, Emmanuelle Pinjon |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
chemistry.chemical_classification
Azoles Ergosterol Antifungal Agents Candidiasis Microbial Sensitivity Tests Biology biology.organism_classification Phenotype Biochemistry Microbiology chemistry.chemical_compound Enzyme chemistry Drug Resistance Fungal Azole Humans Colonization Efflux Candida albicans Candida dubliniensis Candida |
| Zdroj: | ResearcherID |
| ISSN: | 0300-5127 |
| Popis: | Candida dubliniensis is a recently described species of pathogenic yeast that shares many phenotypic features with Candida albicans. It is primarily associated with oral colonization and infection in HIV-infected individuals. Isolates of C. dubliniensis are generally susceptible to commonly used azole antifungal agents; however, resistance has been observed in clinical isolates and can be induced by in vitro exposure. Molecular mechanisms of azole resistance in C. dubliniensis include increased drug efflux, modifications of the target enzyme and alterations in the ergosterol biosynthetic pathway. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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