Evaluation of Phenolic Content Diversity along with Antioxidant/Pro-Oxidant, Glutathione Transferase Inhibition, and Cytotoxic Potential of Selected Commonly Used Plants

Autor: Rasha Awni Guneidy, Eman Ragab Zaki, Abdul Aziz Mohamed Gad, Nevein Salah El-Din Saleh, Abeer Shokeer
Rok vydání: 2022
Předmět:
Zdroj: Preventive nutrition and food science. 27(3)
ISSN: 2287-1098
Popis: The function of antioxidant polyphenols has been demonstrated for their ability to protect against a variety of diseases. However, some antioxidants have been shown to be pro-oxidant. Some of the important antioxidant enzymes are glutathione transferases (GST), which are involved in maintaining redox homeostasis. GST class Pi (GSTP1-1) hyper-activation is a feature that is found in cancer. This work aims to demonstrate the relationship between the phytochemicals of 18 plants and their ability to act as antioxidant/pro-oxidant agents, as well as their effects on the activity of GSTP1-1 and their cellular toxicity.
Databáze: OpenAIRE