Thiol/disulphide homeostasis in intensive care unit patients with sepsis and septic shock
| Autor: | Hamit Yildiz |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Oxidative stress antioxidant level tissue damage critical care patients Blood Sedimentation 030204 cardiovascular system & hematology Gastroenterology Article Procalcitonin law.invention Sepsis 03 medical and health sciences 0302 clinical medicine antioxidant level law Internal medicine medicine Humans Disulfides Sulfhydryl Compounds critical care patients chemistry.chemical_classification 0303 health sciences medicine.diagnostic_test 030306 microbiology Septic shock business.industry tissue damage Organ dysfunction Acute-phase protein General Medicine Middle Aged medicine.disease Shock Septic Intensive care unit Oxidative Stress chemistry Case-Control Studies Erythrocyte sedimentation rate Thiol Female medicine.symptom business |
| Zdroj: | Turkish Journal of Medical Sciences Volume: 50, Issue: 4 811-816 |
| ISSN: | 1303-6165 1300-0144 |
| Popis: | Background/aim: Sepsis is a condition caused by infection followed by unregulated inflammatory response which may lead to organ dysfunction. The aim of this study is to be the first in the literature and it has been designed to show the thiol/disulphide changes in patients with sepsis and septic shock and their correlation with acute phase reactants. Material and methods: A total of 113 patients septic shock 53 and sepsis 60 and 60 healthy control subjects have been enrolled in this study from the period February 2018 to 2019. The patients were divided in 2 groups: nonsurvivors 74 and survivors 39 . The investigation includes measurements of native thiol, total thiol, dynamic disulphide bond, oxidized thiol ratio, reduced thiol ratio and thiol oxidation reduction ratio, erythrocyte sedimentation rate, C-reactive protein, and procalcitonin. Results: The findings of this study suggest that changes in thiol levels play a role in the pathogenesis of patients with sepsis and septic shock. Conclusions: Thiol/disulphide homeostasis is impaired in patients with sepsis and septic shock. Understanding the role of thiol/ disulphide homeostasis in sepsis and septic shock may provide different therapeutic intervention strategies for patients. |
| Databáze: | OpenAIRE |
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