Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
| Autor: | Ramiro Mendonça Murata, Alberto M. Martelli, Piotr Laidler, James A. McCubrey, Steve L. Abrams, Giuseppe Montalto, Saverio Candido, Aurora Scalisi, Melchiorre Cervello, Luca M. Neri, Pedro Luiz Rosalen, Ferdinando Nicoletti, Lucio Cocco, Massimo Libra, Joanna Dulińska-Litewka, Li V. Yang, Dariusz Rakus, Stefano Ratti, Paolo Lombardi, Kvin Lertpiriyapong, Linda S. Steelman, Agnieszka Gizak |
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| Přispěvatelé: | Mccubrey, James A., Lertpiriyapong, Kvin, Steelman, Linda S., Abrams, Steve L., Yang, Li V., Murata, Ramiro M., Rosalen, Pedro L., Scalisi, Aurora, Neri, Luca M., Cocco, Lucio, Ratti, Stefano, Martelli, Alberto M., Laidler, Piotr, Dulinska-Litewka, Joanna, Rakus, Dariusz, Gizak, Agnieszka, Lombardi, Paolo, Nicoletti, Ferdinando, Candido, Saverio, Libra, Massimo, Montalto, Giuseppe, Cervello, Melchiorre, Mccubrey, J., Lertpiriyapong, K., Steelman, L., Abrams, S., Yang, L., Murata, R., Rosalen, P., Scalisi, A., Neri, L., Cocco, L., Ratti, S., Martelli, A., Laidler, P., Dulinska-Litewka, J., Rakus, D., Gizak, A., Lombardi, P., Nicoletti, F., Candido, S., Libra, M., Montalto, G., Cervello, M. |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Aging Curcumin MiR Review Resveratrol Pharmacology CSC Natural product Cell Line NO MiRs 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Berberine Nutraceutical Cancer stem cell Cell Line Tumor Neoplasms microRNA Humans Medicine SIRT Gene methylation Curcuma Natural products Tumor CSCs Curcumin Gene methylation MiRs Natural products Resveratrol SIRT biology business.industry Cell Biology Coptis chinensis biology.organism_classification CSCs Neoplastic Stem Cells Dietary Supplements 030104 developmental biology chemistry 030220 oncology & carcinogenesis business |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| DOI: | 10.18632/aging.101250 |
| Popis: | Natural products or nutraceuticals have been shown to elicit anti-aging, anti-cancer and other health-enhancing effects. A key target of the effects of natural products may be the regulation of microRNA (miR) expression which results in cell death or prevents aging, diabetes, cardiovascular and other diseases. This review will focus on a few natural products, especially on resveratrol (RES), curcumin (CUR) and berberine (BBR). RES is obtained from the skins of grapes and other fruits and berries. RES may extend human lifespan by activating the sirtuins and SIRT1 molecules. CUR is isolated from the root of turmeric (Curcuma longa). CUR is currently used in the tutreatment of many disorders, especially in those involving an inflammatory process. CUR and modified derivatives have been shown to have potent anti-cancer effects, especially on cancer stem cells (CSC). BBR is also isolated from various plants (e.g., Coptis chinensis) and has been used for centuries in traditional medicine to treat diseases such as adult- onset diabetes. Understanding the benefits of these and other nutraceuticals may result in approaches to improve human health. |
| Databáze: | OpenAIRE |
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