Epididymal and testicular sperm for intracytoplasmic sperm injection in the treatment of obstructive azoospermia
| Autor: | Peter Sjöblom, T. Hillensjö, Björn Rosenlund, Anna Dimitrakopoulos |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Cytoplasm endocrine system medicine.medical_specialty medicine.medical_treatment Obstructive azoospermia Fertilization in Vitro Urofollitropin Genitalia Male Intracytoplasmic sperm injection Injections Male infertility Andrology Pregnancy Testis Humans Medicine reproductive and urinary physiology Ovum Epididymis Gynecology Azoospermia urogenital system business.industry Obstetrics and Gynecology Oligospermia General Medicine medicine.disease Sperm Testicular sperm extraction Female Genital Diseases Male business Percutaneous epididymal sperm aspiration medicine.drug |
| Zdroj: | Acta Obstetricia et Gynecologica Scandinavica. 76:135-139 |
| ISSN: | 1600-0412 0001-6349 |
| DOI: | 10.3109/00016349709050069 |
| Popis: | The possibility of treating male infertility because of obstructive azoospermia has been poor, but intracytoplasmic sperm injection (ICSI) has given this type of infertility sufferer a new option.In this study 13 couples with obstructive azoospermia were treated in a total of 19 stimulated IVF cycles. The men were between 27 and 45 (mean 33) years of age. Their partners, 24-39 (mean 31) years of age were treated according to routine IVF procedures, i.e. down regulation with buserelin followed by hyperstimulation with urofollitropin. Fertilization was obtained by ICSI. Two embryos were transferred on day two after the ovum pick up. Sperm were retrieved through microsurgical epididymal aspiration (MESA) in four cycles, percutaneous epididymal sperm aspiration (PESA) in three cycles and through testicular sperm extraction (TESE) in 12 cycles.The overall fertilization rate was 68%, with a cleavage rate of 82%.The fertilization rate was equal (68%) with epididymal and testicular sperm and the cleavage rate was 87%) and 80%, respectively. Embryos were obtained for embryo transfer (ET) in all cases and five pregnancies (one twin pregnancy) were established (26% per ET), three using epididymal sperm and two using testicular sperm.Infertility due to obstructive azoospermia can successfully be treated with epididymal sperm and ICSI. When epididymal sperm cannot be found sperm extracted from a testicular biopsy can be used. PESA and TESE are quicker and easier alternatives to MESA and can be performed on an outpatient basis with local anesthesia. |
| Databáze: | OpenAIRE |
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