Fusobacterium nucleatum — symbiont, opportunist and oncobacterium
| Autor: | Caitlin A. Brennan, Wendy S. Garrett |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Carcinogenesis
Microbiology Article 03 medical and health sciences Oral Microbiota stomatognathic system Humans Symbiosis Genetics Mouth 0303 health sciences Fusobacterium nucleatum Host Microbial Interactions General Immunology and Microbiology biology 030306 microbiology Extramural Fusobacterium Infection Fusobacteria biology.organism_classification stomatognathic diseases Infectious Diseases Fusobacterium Infections Current technology Colorectal Neoplasms Infectious agent |
| Zdroj: | Nature Reviews Microbiology. 17:156-166 |
| ISSN: | 1740-1534 1740-1526 |
| DOI: | 10.1038/s41579-018-0129-6 |
| Popis: | Fusobacterium nucleatum has long been found to cause opportunistic infections and has recently been implicated in colorectal cancer; however, it is a common member of the oral microbiota and can have a symbiotic relationship with its hosts. To address this dissonance, we explore the diversity and niches of fusobacteria and reconsider historic fusobacterial taxonomy in the context of current technology. We also undertake a critical reappraisal of fusobacteria with a focus on F. nucleatum as a mutualist, infectious agent and oncogenic microorganism. In this Review, we delve into recent insights and future directions for fusobacterial research, including the current genetic toolkit, our evolving understanding of its mechanistic role in promoting colorectal cancer and the challenges of developing diagnostics and therapeutics for F. nucleatum. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink