Assessment of hemodynamic and vascular parameters in Alzheimer's disease, vascular dementia and mild cognitive abnormalities: a pilot study
| Autor: | Bruno A. Rezende, Chrystian Junior Rodrigues, Marcus Vinícius Bolívar Malachias, José Ivany dos Santos, Juliana Barroso Zogheib |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Hemodynamics Physical examination 030204 cardiovascular system & hematology Pulse Wave Analysis 03 medical and health sciences 0302 clinical medicine Vascular Stiffness Alzheimer Disease Internal medicine medicine Dementia Prospective cohort study Vascular dementia medicine.diagnostic_test business.industry Dementia Vascular Microangiopathy RC952-954.6 Magnetic resonance imaging General Medicine medicine.disease Geriatrics Arterial stiffness Cardiology business 030217 neurology & neurosurgery |
| Zdroj: | Revista Brasileira de Geriatria e Gerontologia, Vol 20, Iss 5, Pp 670-678 (2017) Revista Brasileira de Geriatria e Gerontologia v.20 n.5 2017 Revista Brasileira de Geriatria e Gerontologia Universidade do Estado do Rio de Janeiro (UERJ) instacron:UFRJ |
| ISSN: | 1981-2256 |
| Popis: | Objectives: this pilot study correlated cardiovascular parameters such as atherosclerosis and arterial stiffness in patients with aged-related dementia and sought to identify hemodynamic differences that can help in differential diagnosis. Method: a longitudinal prospective study was performed of 46 patients aged 60 to 80 years in the city of Belo Horizonte, Minas Gerais, Brazil. The patients were classified into three groups: those with Alzheimer’s disease (AD), vascular dementia (VD) or mild cognitive impairment (MCI). The groups were classified by clinical examination and CT or magnetic resonance imaging tests of the encephalon. The arterial stiffness and other hemodynamic parameters of the patients were measured using the Mobil-O-Graph device and carotid artery ultrasound scanning. Data analysis was performed by descriptive statistics, multinomial logistic regression and analysis of variance. Results: 18 patients (39.1%) had MCI, 18 (39.1%) AD and 10 (21.8%) VD. Image exams revealed greater obstructive microangiopathy in the AD group than the MCI group (p |
| Databáze: | OpenAIRE |
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