Reduction-Triggered Paclitaxel Release Nano-Hybrid System Based on Core-Crosslinked Polymer Dots with a pH-Responsive Shell-Cleavable Colorimetric Biosensor

Autor: Hyun Jeong Won, Pham Thi My Phuong, Seul Gi Kim, Suk Ho Bhang, Benny Ryplida, Gibaek Lee, Sung Young Park
Rok vydání: 2019
Předmět:
Polymers
controllable drug release
Apoptosis
Biosensing Techniques
02 engineering and technology
01 natural sciences
lcsh:Chemistry
chemistry.chemical_compound
Drug Delivery Systems
lcsh:QH301-705.5
Spectroscopy
Drug Carriers
Chemistry
General Medicine
Hydrogen-Ion Concentration
021001 nanoscience & nanotechnology
Glutathione
Fluorescence
Computer Science Applications
Paclitaxel
nano-hybrid matrix
Colorimetry
0210 nano-technology
Hydrophobic and Hydrophilic Interactions
Oxidation-Reduction
endocrine system
Cell Survival
Antineoplastic Agents
010402 general chemistry
Article
Catalysis
Inorganic Chemistry
Hydrophobic effect
Nanosensor
Cell Line
Tumor
Animals
Humans
Physical and Theoretical Chemistry
polymer dots
Molecular Biology
Tumor microenvironment
Organic Chemistry
technology
industry
and agriculture
pH-sensitive
0104 chemical sciences
Drug Liberation
lcsh:Biology (General)
lcsh:QD1-999
Cancer cell
Biophysics
Nanoparticles
redox-responsive
Biosensor
Zdroj: International Journal of Molecular Sciences
Volume 20
Issue 21
International Journal of Molecular Sciences, Vol 20, Iss 21, p 5368 (2019)
ISSN: 1422-0067
DOI: 10.3390/ijms20215368
Popis: Herein, we describe the fabrication and characterization of carbonized disulfide core-crosslinked polymer dots with pH-cleavable colorimetric nanosensors, based on diol dye-conjugated fluorescent polymer dots (L-PD), for reduction-triggered paclitaxel (PTX) release during fluorescence imaging-guided chemotherapy of tumors. L-PD were loaded with PTX (PTX loaded L-PD), via &pi
&ndash
&pi
stackings or hydrophobic interactions, for selective theragnosis by enhanced release of PTX after the cleavage of disulfide bonds by high concentration of glutathione (GSH) in a tumor. The nano-hybrid system showed fluorescence quenching behavior with less than 2% of PTX released under physiological conditions. However, in a tumor microenvironment, the fluorescence recovered at an acidic-pH, and PTX (approximately 100% of the drug release) was released efficiently out of the matrix by reduction caused by the GSH level in the tumor cells, which improved the effectiveness of the cancer treatment. Therefore, the colorimetric nanosensor showed promising potential in distinguishing between normal and cancerous tissues depending on the surrounding pH and GSH concentrations so that PTX can be selectively delivered into cancer cells for improved cancer diagnosis and chemotherapy.
Databáze: OpenAIRE
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