TRPA1 Contributes to Cold, Mechanical, and Chemical Nociception but Is Not Essential for Hair-Cell Transduction
| Autor: | Melissa A. Vollrath, Clifford J. Woolf, Kelvin Y. Kwan, Andrew Allchorne, David P. Corey, Duan-Sun Zhang, Adam Christensen |
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| Rok vydání: | 2006 |
| Předmět: |
Neuroscience(all)
HUMDISEASE Pain Biology Mechanotransduction Cellular MOLNEURO 03 medical and health sciences Transient receptor potential channel Mice 0302 clinical medicine Transient Receptor Potential Channels Dorsal root ganglion Physical Stimulation Hair Cells Auditory medicine TRPM8 otorhinolaryngologic diseases Animals Mechanotransduction TRPA1 Cation Channel Vestibular Hair Cell 030304 developmental biology Mice Knockout 0303 health sciences Brain Mapping Reverse Transcriptase Polymerase Chain Reaction General Neuroscience food and beverages Nociceptors Cold Temperature medicine.anatomical_structure SIGNALING Nociceptor Auditory Perception Hair cell sense organs Transduction (physiology) Neuroscience 030217 neurology & neurosurgery psychological phenomena and processes |
| Zdroj: | Neuron. 50(2):277-289 |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/j.neuron.2006.03.042 |
| Popis: | TRPA1, a member of the transient receptor potential (TRP) family of ion channels, is expressed by dorsal root ganglion neurons and by cells of the inner ear, where it has proposed roles in sensing sound, painful cold, and irritating chemicals. To test the in vivo roles of TRPA1, we generated a mouse in which the essential exons required for proper function of the Trpa1 gene were deleted. Knockout mice display behavioral deficits in response to mustard oil, to cold ( approximately 0 degrees C), and to punctate mechanical stimuli. These mice have a normal startle reflex to loud noise, a normal sense of balance, a normal auditory brainstem response, and normal transduction currents in vestibular hair cells. TRPA1 is apparently not essential for hair-cell transduction but contributes to the transduction of mechanical, cold, and chemical stimuli in nociceptor sensory neurons. |
| Databáze: | OpenAIRE |
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