Effect of the arginine-containing mu,delta-opiate receptor agonist sedatin on DNA synthesis in the epithelium of the gastric fundus in albino rats
| Autor: | V. I. Deigin, A. V. Kuznetsov, M. Yu. Fleishman, Timoshin Ss |
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| Rok vydání: | 2004 |
| Předmět: |
Agonist
Male medicine.medical_specialty Arginine medicine.drug_class medicine.medical_treatment Intraperitoneal injection Receptors Opioid mu Biology General Biochemistry Genetics and Molecular Biology Internal medicine Receptors Opioid delta Gastric mucosa medicine Animals Receptor Administration Intranasal DNA synthesis General Medicine DNA Epithelium Rats medicine.anatomical_structure Endocrinology Gastric Mucosa Nasal administration Oligopeptides Injections Intraperitoneal Histamine |
| Zdroj: | Bulletin of experimental biology and medicine. 137(3) |
| ISSN: | 0007-4888 |
| Popis: | We studied the effect of arginine-containing mu,delta-opiate receptor agonist sedatin on DNA synthesis in the epithelium of the gastric fundus in albino rats. Fivefold intraperitoneal injection of sedatin in various doses increased the index of labeled nuclei. Similar changes were observed after intranasal and intraperitoneal treatment with sedatin in a dose of 10 microg/kg for 21 days. Administration of sedatin for 21 days prevented the decrease in weight gain induced by experimental stress. Our results suggest that arginine entering the composition of sedatin plays a role in its biological effects. |
| Databáze: | OpenAIRE |
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