Intra-Articular Bone Marrow Aspirate Concentrate Injection in Patients with Knee Osteoarthritis
| Autor: | Jae Do Kim, Gi Beom Kim, Chang Hyun Choi, Gun Woo Lee, Young Sang Choi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Visual analogue scale knee Osteoarthritis Knee Joint lcsh:Technology lcsh:Chemistry 03 medical and health sciences 0302 clinical medicine Bone marrow aspirate Primary outcome Intra articular bone marrow aspirate concentrate medicine General Materials Science In patient lcsh:QH301-705.5 Instrumentation 030203 arthritis & rheumatology Fluid Flow and Transfer Processes 030222 orthopedics lcsh:T business.industry Process Chemistry and Technology General Engineering musculoskeletal system medicine.disease clinical outcomes lcsh:QC1-999 Computer Science Applications Surgery osteoarthritis lcsh:Biology (General) lcsh:QD1-999 lcsh:TA1-2040 lcsh:Engineering (General). Civil engineering (General) business Tegner Activity Scale human activities lcsh:Physics |
| Zdroj: | Applied Sciences, Vol 10, Iss 5945, p 5945 (2020) Applied Sciences Volume 10 Issue 17 |
| ISSN: | 2076-3417 |
| DOI: | 10.3390/app10175945 |
| Popis: | We aimed to evaluate the 5-year follow-up outcomes of an intra-articular bone marrow aspirate concentrate (BMAC) injection in patients with knee osteoarthritis. This is the first study to report the outcomes following BMAC injections over a 5-year follow-up period. Seventy knees of 37 patients, including 33 bilateral knees, were investigated. The primary outcome was the visual analogue scale (VAS) score for pain in the knee joint, and the secondary outcomes were the International Knee Documentation Committee score, the 36-Item Short Form Health Survey score, the Knee injury Osteoarthritis Outcome Score, Lysholm Knee Questionnaire/Tegner activity scale, BMAC injection-induced complications, and 5-year treatment success rate. The 5-year post-injection VAS scores (4.7 ± 0.5) were significantly lower than the preoperative scores (8.3 ± 1.2) (p = 0.01). Improvement in VAS scores was significantly greater in patients with Kellgren&ndash Lawrence (K-L) Grade I or II than those in those with K-L Grade III or IV. Improvement in other clinical parameters and success rates were significantly low and the rates of secondary operation and failure were significantly higher in patients with K-L Grades III or IV. Intra-articular BMAC injections could be useful for managing patients with K-L Grades I or II osteoarthritis. |
| Databáze: | OpenAIRE |
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