Selectin polymorphisms and perinatal morbidity in low-birthweight infants
| Autor: | László Derzbach, János Rigó, Géza Bokodi, András Nobilis, Barna Vásárhelyi, András Treszl |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Genotype Sepsis Epidemiology medicine Humans L-Selectin Allele Bronchopulmonary Dysplasia Polymorphism Genetic Obstetrics business.industry Infant Newborn General Medicine Infant Low Birth Weight medicine.disease P-Selectin Low birth weight Bronchopulmonary dysplasia Premature birth Bacteremia Pediatrics Perinatology and Child Health Immunology Selectins Female Morbidity medicine.symptom E-Selectin business Infant Premature |
| Zdroj: | Acta Paediatrica. 95:1213-1217 |
| ISSN: | 0803-5253 |
| DOI: | 10.1080/08035250600575404 |
| Popis: | Background: Studies have shown an association between altered expression of selectins and premature birth, early sepsis and bronchopulmonary dysplasia. Aim: To investigate the possible link between functional polymorphisms of the E-, P- and L-selectin genes and perinatal morbidity. Methods: We compared the genotype distribution of the E-selectin Ser128Arg, P-selectin Thr715Pro and L-selectin Pro213Ser polymorphisms in 125 low-birthweight singleton infants with those of 156 healthy term neonates. We also analysed the association of genotype with risk of sepsis and bronchopulmonary dysplasia. Results: We found no association between E-selectin or P-selectin polymorphisms and premature birth, nor did we find any association between E-selectin or P-selectin and early postnatal sepsis or bronchopulmonary dysplasia. Carriers of the 213Ser L-selectin allele were found to be more prevalent in low-birthweight infants, particularly in those with bronchopulmonary dysplasia. We found no association between the L-selectin polymorphism and early postnatal sepsis. Conclusion: Our results underline the importance of L-selectin in perinatal pathology, but further studies are needed to evaluate the alteration of L-selectin levels in carriers of the 213Ser allele and their possible contribution to premature birth and bronchopulmonary dysplasia. |
| Databáze: | OpenAIRE |
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