Non-Hydrolyzable RNA-Peptide Conjugates: A Powerful Advance in the Synthesis of Mimics for 3′-Peptidyl tRNA Termini
| Autor: | Krista Trappl, Ronald Micura, Katja Fauster, Jessica Steger, Holger Moroder, Dagmar Graber, Viter Márquez, Norbert Polacek, Daniel N. Wilson |
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| Rok vydání: | 2009 |
| Předmět: |
Base Sequence
Chemistry Stereochemistry Oligonucleotide Hydrolysis Molecular Mimicry RNA Translation (biology) General Medicine General Chemistry RNA Transfer Amino Acyl Ribosome Catalysis Solid-phase synthesis Structural biology Protein Biosynthesis Transfer RNA Protein biosynthesis Amino Acid Sequence Peptides |
| Zdroj: | Angewandte Chemie International Edition. 48:4056-4060 |
| ISSN: | 1521-3773 1433-7851 |
| Popis: | Translation of specific small peptides on the ribosome can confer resistance to macrolide antibiotics. To reveal the molecular details of this and related phenomena, stable RNA-peptide conjugates that mimic peptidyl-tRNA would be desirable, especially for ribosome structural biology. A flexible solid-phase synthesis strategy now allows efficient access to these highly requested derivatives without restriction on the RNA and peptide sequences. |
| Databáze: | OpenAIRE |
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