| Autor: |
Rimsha Bhatta, Joonsu Han, Yusheng Liu, Yang Bo, Hua Wang |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Biomaterials. 293:121972 |
| ISSN: |
0142-9612 |
| DOI: |
10.1016/j.biomaterials.2022.121972 |
| Popis: |
Adoptive T cell therapy has demonstrated great promise for treating cancer and other diseases. While extensive effort has been made to improve ex vivo expansion of T cells, strategies for maintaining the proliferation and function of T cells post adoptive transfer are still lacking. Here we report an injectable T cell-responsive macroporous hydrogel that enables in situ activation and expansion of T cells. The macroporous gel is composed of a polymeric network with dispersed macropores (∼150 μm) that are large enough to home T cells. In the presence of T cells that can gradually disrupt the gel network surrounding the macropores, activation cues can be gradually released for in situ activation and expansion of T cells. This T cell-responsive macroporous gel enables expansion of effector T cells in vivo, is stable over weeks upon subcutaneous injection, and results in enhanced CD8 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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