Emergence in Brazil of methicillin-resistant Staphylococcus aureus isolates carrying SCCmecIV that are related genetically to the USA800 clone
| Autor: | N. Caetano, R.P. Cordeiro, O.P. de Miranda, Apoena de Aguiar Ribeiro, M.C. Silva-Carvalho, C.F.L. Vidal, F. Portela, Agnes Marie Sá Figueiredo |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
DNA Bacterial Microbiology (medical) Staphylococcus aureus Genotype methicillin-resistant Staphylococcus aureus Biology Staphylococcal infections medicine.disease_cause Microbiology SCCmecIV medicine Pulsed-field gel electrophoresis Humans Child Aged Aged 80 and over Cross Infection Molecular Epidemiology paediatric clone Molecular epidemiology Clonal complex 5 Incidence Sequence Analysis DNA General Medicine Middle Aged Staphylococcal Infections medicine.disease USA800 DNA Fingerprinting Methicillin-resistant Staphylococcus aureus Bacterial Typing Techniques Electrophoresis Gel Pulsed-Field Infectious Diseases Carriage pulsed-field gel electrophoresis Biofilms Child Preschool Multilocus sequence typing Methicillin Resistance Brazil |
| Zdroj: | Clinical Microbiology and Infection. 13:1165-1172 |
| ISSN: | 1198-743X |
| DOI: | 10.1111/j.1469-0691.2007.01830.x |
| Popis: | An increasing incidence of nosocomial infections caused by non-multiresistant methicillin-resistant Staphylococcus aureus (nMMRSA) has been reported worldwide. The present study genotyped nMMRSA isolates obtained from hospitals in two cities in Brazil. The hospital isolates displayed pulsed-field gel electrophoresis (PFGE) patterns that were similar to those of the USA100 (ST5-SCCmecII) and USA 800 (ST5-SCCmecIV) strains, which are related to the New York/Japan and paediatric clones, respectively. Carriage of SCCmecIV and the classification by multilocus sequence typing (MLST) of a representative of this PFGE pattern in clonal complex 5 (CC5) confirmed the genetic relationship of the Brazilian isolates with USA800. The USA800-related Brazilian isolates were responsible for severe nosocomial infections in compromised adults and elderly patients in Brazil. A higher growth rate, an ability to form biofilm on inert polystyrene surfaces and the presence of the egc locus may have contributed, at least in part, to the fitness of these organisms as global nosocomial pathogens. |
| Databáze: | OpenAIRE |
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