Equol production changes over time in postmenopausal women
| Autor: | Howard N. Hodis, Naoko Kono, Ian Pagano, Wendy J. Mack, Jennifer F. Lai, Adrian A. Franke, Brunhild M. Halm |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Time Factors medicine.drug_class Endocrinology Diabetes and Metabolism Clinical Biochemistry Population Antibiotics Urine Placebo Biochemistry Article Specimen Handling law.invention chemistry.chemical_compound Animal science Double-Blind Method Randomized controlled trial law Internal medicine medicine Humans education Molecular Biology Urine Specimen Collection education.field_of_study Creatinine Nutrition and Dietetics business.industry Daidzein Equol Middle Aged Isoflavones Anti-Bacterial Agents Postmenopause Endocrinology chemistry Soybean Proteins Female business |
| Zdroj: | The Journal of Nutritional Biochemistry. 23:573-579 |
| ISSN: | 0955-2863 |
| DOI: | 10.1016/j.jnutbio.2011.03.002 |
| Popis: | Equol (EQ) is produced by intestinal bacteria from the soy isoflavone daidzein (DE) in 30%-60% of the population and is believed to provide benefits from soy intake. A robust EQ status definition is lacking, and it is uncertain whether EQ is formed consistently within an individual and ceases upon oral antibiotic treatment. In a randomized, double-blind, placebo-controlled soy intervention trial with 350 postmenopausal women, DE and EQ were analyzed by liquid chromatography/tandem mass spectrometry at baseline and every 6 months over 2.5 years in overnight urine, spot urine and plasma. Equol production changes and status (remaining an EQ producer or nonproducer or changing towards an EQ producer or nonproducer) were assessed. Equol status was determined most dependably by overnight urine applying as cutoff a ratio of EQ/DE≥0.018 with a DE threshold ≥2 nmol/mg creatinine: the soy and placebo groups had approximately 30% consistent EQ producers during the study, but 14% and 35%, respectively, changed EQ status (mean 1.4-1.7 times), while 27% and 17%, respectively, had antibiotic treatment (P |
| Databáze: | OpenAIRE |
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