L-arginine and N-carbamoylglutamic acid supplementation enhance young rabbit growth and immunity by regulating intestinal microbial community
| Autor: | Hao Jiang, Yan Gao, Jia-Bao Zhang, Xianmei Meng, Xiaoming Sun, Sheng Li, Cheng-Zhen Chen, Bao Yuan, Chang Liu, Yan-Xia Peng, Jinglin Shen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
intestinal microbial community
medicine.medical_specialty n-carbamoylglutamic acid Protein efficiency ratio japanese white rabbits lcsh:Animal biochemistry Weanling Ileum digestive system Article Jejunum Internal medicine medicine l-arginine intestinal development lcsh:QP501-801 lcsh:SF1-1100 biology Intestinal villus 0402 animal and dairy science 04 agricultural and veterinary sciences Metabolism biology.organism_classification 040201 dairy & animal science Animal Biotechnology medicine.anatomical_structure Endocrinology Animal Science and Zoology lcsh:Animal culture Bacteroides Roseburia Food Science |
| Zdroj: | Asian-Australasian Journal of Animal Sciences, Vol 33, Iss 1, Pp 166-176 (2020) Asian-Australasian Journal of Animal Sciences |
| ISSN: | 1976-5517 1011-2367 |
| DOI: | 10.5713/ajas.18.0984 |
| Popis: | Objective An experiment was conducted to determine the effects of L-arginine (L-Arg) and N-carbamoylglutamic acid (NCG) on the growth, metabolism, immunity and community of cecal bacterial flora of weanling and young rabbits. Methods Eighteen normal-grade male weanling Japanese White Rabbits (JWR) were selected and randomly divided into 6 groups with or without L-Arg and NCG supplementation. The whole feeding process was divided into weanling stage (Day 37 to 65) and young stage (Day 66 to 85). The effects of L-Arg and NCG on the growth, metabolism, immunity and development of the ileum and jejunum were compared via nutrient metabolism experiments and histological assessment. The different communities of cecal bacterial flora affected by L-Arg and NCG were assessed using high-throughput sequencing technology and bioinformatics analysis. Results The addition of L-Arg and NCG were able to enhance the growth of weanling and young rabbit by increasing the nitrogen metabolism, protein efficiency ratio, and biological value, as well as feed intake, daily weight gain. Both L-Arg and NCG were able to increase the concentration of IgA, IgM, and IgG. NCG was superior to L-Arg in promoting intestinal villus development by increasing villus height and V/C index, reducing the crypt depth. The effects of L-Arg and NCG on the cecal bacterial flora were mainly concentrated in different genera, including Parabacteroides, Roseburia, dgA-11_gut_group, Alistipes, Bacteroides, and Ruminococcaceae_UCG-005. These bacteria function mainly in amino acid transport and metabolism, energy production and conversion, lipid transport and metabolism, recombination and repair, cell cycle control, cell division, and cell motility. Conclusion L-Arg and NCG have promotional ability on the growth and immunity of weanling and young Japanese White Rabbits, as well as their effects on the jejunum and ileum villi. L-Arg and NCG have different effects in the promotion of nutrient utilization, relieving inflammation and enhancing adaptability through regulating microbial community. |
| Databáze: | OpenAIRE |
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