Lipoprotein particles in homozygous familial hypercholesterolemic patients treated with portacaval shunt and LDL apheresis
| Autor: | Philippe Amouyel, Patrick Duriez, C Cachera, Albert Tacquet, Jean-Charles Fruchart, Francoise Monard, Jean-Marie Bard, Dominique Gairin |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent Apolipoprotein B Lipoproteins Clinical Biochemistry Portacaval Portacaval shunt Familial hypercholesterolemia Biochemistry Lipoprotein particle Hyperlipoproteinemia Type II Internal medicine medicine Humans biology Portacaval Shunt Surgical Chemistry Biochemistry (medical) General Medicine medicine.disease Lipids Apolipoproteins Endocrinology Apheresis LDL apheresis Blood Component Removal biology.protein Female lipids (amino acids peptides and proteins) Lipoprotein |
| Zdroj: | Clinica Chimica Acta. 193:165-179 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/0009-8981(90)90248-q |
| Popis: | Lipoprotein particles containing apolipoproteins (Apo) were studied by enzyme-linked-immunosorbent assay in two homozygous familial hypercholesterolemic patients (1 male and 1 female) with portacaval shunts, and in controls. Total Apo B, total cholesterol and LDL cholesterol were increased in both patients while complex Apo B containing particles, Lp CIII : B, were not increased in these FH patients. The dextran-sulfate cellulose columns (Liposorber LA-40) had an excellent adsorption selectivity and adsorption capacity for lipoprotein particles containing Apo B and a minimum adsorption capacity in Apo AI and Apo All-containing particles. This apheresis technique selectively depleted plasma of atherogenic Apo B-containing particles with a minimal loss of antiatherogenic Apo AI-containing particles. |
| Databáze: | OpenAIRE |
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