Evolutionary aspects and enzymology of metazoan carotenoid cleavage oxygenases
| Autor: | Eugenia Poliakov, Susan Gentleman, T. Michael Redmond, Igor B. Rogozin, Sheetal Uppal |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
cis-trans-Isomerases
Oxygenase macromolecular substances Cleavage (embryo) Article Dioxygenases Conserved sequence Evolution Molecular 03 medical and health sciences Animals Molecular Biology Carotenoid beta-Carotene 15 15'-Monooxygenase 030304 developmental biology Mammals chemistry.chemical_classification 0303 health sciences biology Carotenoid oxygenase fungi 030302 biochemistry & molecular biology food and beverages Cell Biology Lipid Metabolism biology.organism_classification Carotenoids Enzyme chemistry Biochemistry RPE65 Oxygenases biology.protein Bacteria |
| Zdroj: | Biochim Biophys Acta Mol Cell Biol Lipids |
| ISSN: | 1388-1981 |
| Popis: | The carotenoids are terpenoid fat-soluble pigments produced by plants, algae, and several bacteria and fungi. They are ubiquitous components of animal diets. Carotenoid cleavage oxygenase (CCO) superfamily members are involved in carotenoid metabolism and are present in all kingdoms of life. Throughout the animal kingdom, carotenoid oxygenases are widely distributed and they are completely absent only in two unicellular organisms, Monosiga and Leishmania. Mammals have three paralogs 15,15’-β-carotene oxygenase (BCO1), 9’,10’-β-carotene oxygenase (BCO2) and RPE65. The first two enzymes are classical carotenoid oxygenases: they cleave carbon-carbon double bonds and incorporate two atoms of oxygen in the substrate at the site of cleavage. The third, RPE65, is an unusual family member, it is the retinoid isomerohydrolase in the visual cycle that converts all-trans-retinyl ester into 11-cis-retinol. Here we discuss evolutionary aspects of the carotenoid cleavage oxygenase superfamily and their enzymology to deduce what insight we can obtain from their evolutionary conservation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect