The effect of diazepam in the recovery of rabbits from acute acetaminophen intoxication
| Autor: | Gideon Eshel, G Lushkov, Zehava Chen-Levy, Gideon Koren, Ora Pinto, Matitiahu Berkovitch, Svetlana Reznik |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
acetaminophen overdose Analgesic Drug Evaluation Preclinical Administration Oral Medicine Animals Urea Pharmacology (medical) Antipyretic Aspartate Aminotransferases Acetaminophen Pharmacology Diazepam biology business.industry Alanine Transaminase Analgesics Non-Narcotic Survival Rate Treatment Outcome Alanine transaminase Anesthesia Creatinine Toxicity Acute Disease biology.protein Rabbits business Intramuscular injection medicine.drug |
| Zdroj: | Therapeutic drug monitoring. 21(3) |
| ISSN: | 0163-4356 |
| Popis: | We have recently shown that diazepam can reduce mortality of acute iron overdose in rats. The mechanism for that effect is not yet defined. Our objective in the present study was to assess whether diazepam can similarly reduce mortality of experimental acute acetaminophen intoxication. Survival of rabbits was compared among four groups receiving 3 g/kg (body weight) of acetaminophen (LD40) orally each, followed by: 1) nothing (group I), 2) one oral dose of 140 mg/kg N-acetylcystein (NAC) an hour later (group II), 3) intramuscular injection of 7 mg/kg diazepam (group III), 4) intramuscular injection of 7 mg/kg diazepam and one oral dose of 140 mg/kg NAC an hour later (group IV). 37.5% of rabbits in group I died after 16 hours, whereas none of the rabbits in group III died, (p = 0.04). No animal died during the 96-hour observation period in groups II and IV. Two and four hours post drug administration, acetaminophen plasma concentrations (APC) were significantly lower among rabbits in group III than in group I (p = 0.0007 and 0.01, respectively) and significantly lower among rabbits in group IV than in those in group II (p |
| Databáze: | OpenAIRE |
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