Propranolol and sotalol augment the coronary vasodilatory action of prostacyclin (PGI2) in rabbit isolated hearts
| Autor: | John E. Atkinson, John A. Turbek, Mark N. Gillespie, Louis Diamond |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
medicine.medical_specialty
Vasodilation Prostacyclin Propranolol In Vitro Techniques Pharmacology Internal medicine medicine Animals Chemistry Constant flow Sotalol Drug Synergism Heart Epoprostenol Perfusion Hypertension Prostaglandins cardiovascular system Cardiology Coronary perfusion pressure lipids (amino acids peptides and proteins) Rabbits Prostacyclin PGI2 medicine.drug |
| Zdroj: | European Journal of Pharmacology. 75:155-158 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(81)90077-7 |
| Popis: | In rabbit isolated hearts perfused at constant flow with Krebs-Henseleit solution, prostacyclin (PGI2, 0.1–10.0 ng/heart) evoked dose-dependent reductions in coronary perfusion pressure. The magnitude of PGI2-induced vasodilator responses was augmented significantly by addition of either propranolol (1 μg/ml, P |
| Databáze: | OpenAIRE |
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