Sex-Biased Molecular Signature for Overall Survival of Liver Cancer Patients
Autor: | Hye Kyung Song, Sun Young Kim, Hyun Goo Woo, Suk Kyeong Lee, Sang Geon Kim, Hyun-Jin Noh, Aree Moon, Jieun Yang, You-Sun Kim |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Review SRPK1 Biochemistry 03 medical and health sciences GSTP1 Sex/gender 0302 clinical medicine Internal medicine Drug Discovery medicine Molecular signature Overall survival Pharmacology BAP1 business.industry Incidence (epidemiology) Cancer medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Molecular Medicine Gene expression FOXA1 Liver cancer business Hormone |
Zdroj: | Biomolecules & Therapeutics |
ISSN: | 2005-4483 1976-9148 |
Popis: | Sex/gender disparity has been shown in the incidence and prognosis of many types of diseases, probably due to differences in genes, physiological conditions such as hormones, and lifestyle between the sexes. The mortality and survival rates of many cancers, especially liver cancer, differ between men and women. Due to the pronounced sex/gender disparity, considering sex/ gender may be necessary for the diagnosis and treatment of liver cancer. By analyzing research articles through a PubMed literature search, the present review identified 12 genes which showed practical relevance to cancer and sex disparities. Among the 12 sex-specific genes, 7 genes (BAP1, CTNNB1, FOXA1, GSTO1, GSTP1, IL6, and SRPK1) showed sex-biased function in liver cancer. Here we summarized previous findings of cancer molecular signature including our own analysis, and showed that sexbiased molecular signature CTNNB1High, IL6High, RHOAHigh and GLIPR1Low may serve as a female-specific index for prediction and evaluation of OS in liver cancer patients. This review suggests a potential implication of sex-biased molecular signature in liver cancer, providing a useful information on diagnosis and prediction of disease progression based on gender. |
Databáze: | OpenAIRE |
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