Leukocytoclastic Vasculitis Associated with Bortezomib Therapy
| Autor: | Mervin Edwin Fernando, Suren Sujith, N D Srinivasaprasad, Kaliaperumal Thirumalvalavan, R Vairakkani, Thiagarajan Raj Yashwanth |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Transplantation
medicine.medical_specialty Creatinine medicine.diagnostic_test business.industry Bortezomib medicine.medical_treatment lcsh:R lcsh:Medicine medicine.disease Gastroenterology chemistry.chemical_compound Intravenous Immunoglobulin Therapy Peripheral neuropathy chemistry Nephrology Internal medicine Biopsy medicine Vomiting Hemodialysis medicine.symptom Vasculitis business medicine.drug |
| Zdroj: | Saudi Journal of Kidney Diseases and Transplantation, Vol 31, Iss 5, Pp 1106-1109 (2020) |
| ISSN: | 1319-2442 |
| DOI: | 10.4103/1319-2442.301178 |
| Popis: | A 28-year-old male, 10 years post live-related renal transplant with stable graft function of 1.4 mg/dL, presented with complaints of loss of appetite and vomiting for three days. On evaluation, he was found to have significant graft dysfunction with a creatinine of 10.3 mg/dL. He was initiated on hemodialysis in view of uremic gastrointestinal symptoms. Graft biopsy done revealed acute cell-mediated rejection BANFF IIB and diffuse C4d-positive antibody-mediated rejection. He was treated with intravenous methylprednisolone, therapeutic plasma exchange, and intravenous immunoglobulin therapy, following which his graft function improved gradually. He received multiple injections of bortezomib as a part of anti-rejection treatment protocol and developed peripheral neuropathy, leukocytoclastic vasculitis, and varicellosis. This case report is to highlight the unusual phenomenon of leukocytoclastic vasculitis in a post renal transplant setting secondary to bortezomib therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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