Structure-activity relationships of inverse agonists for G-protein-coupled receptors
| Autor: | Ineke Van Wijngaarden, Willem Soudijn, Adriaan P. IJzerman |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Agonist
medicine.drug_class Constitutively active Muscarinic Agonists Receptors G-Protein-Coupled Histamine Agonists Structure-Activity Relationship Adenosine A3 Receptor Agonists Drug Discovery Adrenergic alpha-2 Receptor Agonists medicine Animals Humans Inverse agonist Receptor G protein-coupled receptor Cannabinoid Receptor Agonists Pharmacology Chemistry fungi food and beverages Adrenergic beta-Agonists Adenosine A1 Receptor Agonists Serotonin Receptor Agonists Cell biology Dopamine Agonists Molecular Medicine Adrenergic alpha-1 Receptor Agonists |
| Zdroj: | Medicinal Research Reviews. 25:398-426 |
| ISSN: | 1098-1128 0198-6325 |
| DOI: | 10.1002/med.20031 |
| Popis: | It has been recently established that G-protein-coupled receptors (GPCRs) can be constitutively active, i.e., they can be active in the absence of an agonist. This activity can be inhibited by so-called inverse agonists. For a number of GPCRs, such inverse agonists have been developed and studied, now enabling for the first time a study into their structure-activity relationships. |
| Databáze: | OpenAIRE |
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