Environmental enrichment modulates 5-hydroxymethylcytosine dynamics in hippocampus
| Autor: | R. Craig Street, Bing Yao, Hasan A. Irier, Ronak Dave, Timothy Hayden Davis, Li Lin, Peng Jin, Ying Cheng, Catherine W. Cai |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Aging
Hippocampus Biology Article Cytosine Mice chemistry.chemical_compound Genetics Animals Learning Epigenetics Regulation of gene expression 5-Hydroxymethylcytosine Environmental enrichment DNA methylation Enriched environment Axon guidance Cell biology 5-Methylcytosine Gene Expression Regulation chemistry Gene-Environment Interaction 5hmC |
| Zdroj: | Genomics. 104(5):376-382 |
| ISSN: | 0888-7543 |
| DOI: | 10.1016/j.ygeno.2014.08.019 |
| Popis: | Gene–environment interactions mediated at the epigenetic level may provide an initial step in delivering an appropriate response to environmental changes. 5-Hydroxymethylcytosine (5hmC), a DNA base derived from 5-methylcytosine (5mC), accounts for ~40% of modified cytosine in the brain and has been implicated in DNA methylation-related plasticity. To identify the role of 5hmC in gene–environment interactions, we exposed both young (6-week-old) and aged (18-month-old) mice to both an enriched environment and a standard environment. Exposure to EE significantly improves learning and memory in aged mice and reduces 5hmC abundance in mouse hippocampus. Furthermore, we mapped the genome-wide distribution of 5hmC and found that the alteration of 5hmC modification occurred mainly at gene bodies. In particular, genes involved in axon guidance are enriched among the genes with altered 5hmC modification. These results together suggest that environmental enrichment could modulate the dynamics of 5hmC in hippocampus, which could potentially contribute to improved learning and memory in aged animals. |
| Databáze: | OpenAIRE |
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