The influence of L-opsin gene polymorphisms and neural ageing on spatio-chromatic contrast sensitivity in 20–71 year olds
| Autor: | Rigmor C. Baraas, Elise W. Dees, Stuart J. Gilson, Maureen Neitz |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Aging Opsin medicine.medical_specialty genetic structures Color vision Color space Biology Stimulus (physiology) Audiology Polymorphism Single Nucleotide law.invention Contrast Sensitivity Young Adult Optics law OPN1MW medicine Humans Aged Color Vision Opsins business.industry Middle Aged Sensory Systems Ophthalmology Achromatic lens Ageing OPN1LW Female business Color Perception Photic Stimulation |
| Zdroj: | Vision Research. 116:13-24 |
| ISSN: | 0042-6989 |
| DOI: | 10.1016/j.visres.2015.08.015 |
| Popis: | Chromatic contrast sensitivity may be a more sensitive measure of an individual's visual function than achromatic contrast sensitivity. Here, the first aim was to quantify individual- and age-related variations in chromatic contrast sensitivity to a range of spatial frequencies for stimuli along two complementary directions in color space. The second aim was to examine whether polymorphisms at specific amino acid residues of the L- and M-opsin genes (OPN1LW and OPN1MW) known to affect spectral tuning of the photoreceptors could influence spatio-chromatic contrast sensitivity. Chromatic contrast sensitivity functions were measured in 50 healthy individuals (20-71 years) employing a novel pseudo-isochromatic grating stimulus. The spatio-chromatic contrast sensitivity functions were found to be low pass for all subjects, independent of age and color vision. The results revealed a senescent decline in spatio-chromatic contrast sensitivity. There were considerable between-individual differences in sensitivity within each age decade for individuals 49 years old or younger, and age did not predict sensitivity for these age decades alone. Forty-six subjects (including a color deficient male and eight female carriers) were genotyped for L- and M-opsin genes. The Ser180Ala polymorphisms on the L-opsin gene were found to influence the subject's color discrimination and their sensitivity to spatio-chromatic patterns. The results expose the significant role of neural and genetic factors in the deterioration of visual function with increasing age. |
| Databáze: | OpenAIRE |
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