Ethanol Extract of Liriope platyphylla Root Attenuates Non-Alcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Mice via Regulation of Lipogenesis and Lipid Uptake
| Autor: | Hojung Choi, Trang Nu Huyen Le, Hee-Sook Jun |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
CD36 Liriope platyphylla Liver disease lipid uptake NAFLD Internal medicine Diabetes mellitus medicine TX341-641 lipogenesis chemistry.chemical_classification Nutrition and Dietetics biology Nutrition. Foods and food supply Metabolic disorder Fatty liver nutritional and metabolic diseases Fatty acid medicine.disease Obesity Endocrinology chemistry Lipogenesis biology.protein lipids (amino acids peptides and proteins) Food Science |
| Zdroj: | Nutrients, Vol 13, Iss 3338, p 3338 (2021) Nutrients Volume 13 Issue 10 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu13103338 |
| Popis: | Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disorder that causes excess lipid accumulation in the liver and is the leading cause of end-stage liver disease. Liriope platyphylla is a medicinal herb that has long been used to treat cough, obesity, and diabetes. However, the effect of Liriope platyphylla on NAFLD has not been studied. The aim of this study was to investigate the effect of Liriope platyphylla root ethanolic extract (LPE) on hepatic lipid accumulation in high-fat diet (HFD)-induced obese mice. Six-week-old C57BL/6 male mice were fed a HFD for 8 weeks and then treated with LPE (100 or 250 mg/kg/day) by oral gavage for another 8 weeks. Body weight gain and liver weight were significantly lower in the 250 mg/kg LPE-treated HFD group than in the vehicle-treated HFD group. Histological analysis of liver sections demonstrated that LPE treatment reduced lipid accumulation compared to the vehicle treatment. The serum total cholesterol, AST, and ALT levels significantly decreased in the LPE-treated HFD group compared to those in the vehicle-treated HFD group. The LPE significantly decreases the protein expression levels of SREBP1, ACC, p-ACC, FAS, and SCD1, which are involved in lipogenesis, and PPARγ, CD36/FAT, and FATP5, which are involved in fatty acid uptake, both in vivo and in vitro. Thus, LPE may attenuate HFD-induced NAFLD by decreasing lipid accumulation by inhibiting lipogenesis and fatty acid uptake. |
| Databáze: | OpenAIRE |
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