Predictors of Local Control for Stereotactic Ablative Radiotherapy (SAbR) in Pulmonary Oligometastases from Gastrointestinal Malignancies
| Autor: | Carlo Cavedon, N.L.V. Cernusco, Renzo Mazzarotto, Michele Milella, G. Rossi, Alessandro Muraglia, Mario De Liguoro, Stefania Guariglia, M. Pavarana, R. Micera, N. Simoni, Maria Grazia Giri |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Lung Neoplasms gastrointestinal tumors medicine.medical_treatment Observational analysis oligometastatic disease Radiosurgery SABR volatility model Effective dose (radiation) Dose-Response Relationship Ablative case 80 and over Clinical endpoint medicine Humans Oligometastatic disease Aged Gastrointestinal Neoplasms Aged 80 and over Radiation Lung business.industry lung metastases Dose-Response Relationship Radiation General Medicine Middle Aged Radiation therapy medicine.anatomical_structure Oncology Female Radiology business SAbR |
| Zdroj: | Anticancer Research. 40:5901-5907 |
| ISSN: | 1791-7530 0250-7005 |
| Popis: | Background/aim To assess predictors of local control (LC) for stereotactic ablative radiotherapy (SAbR) in pulmonary oligometastatic disease (OMD) from gastrointestinal (GI) malignancies. Patients and methods Patients with pulmonary OMD treated with SAbR from January 2016 to December 2018 were included in this observational analysis. Primary endpoint was LC. Uni- and multivariate analyses to assess variable correlations were conducted. Results Thirty-seven patients and 59 lung metastases were evaluated. The delivered dose was 30-60 Gy in 3-8 fractions. After a median follow-up of 23.0 months (range=6.3-50.4 months), LC rate at 1/2 years was 89.7%/85.0%, and increased to 96.0%/91.0% for lesions treated with a biologically effective dose (BED10) ≥100 Gy (p=0.03). RECIST response at 6 months was predictive for LC (p=0.002). Conclusion SAbR is an effective option for pulmonary OMD from GI malignancies. A BED10 ≥100 Gy and radiological response at 6 months can affect LC. |
| Databáze: | OpenAIRE |
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