Bitter melon seed oil may reduce the adiposity through the hypothalamus mTOR signaling in mice fed a high fat diet
| Autor: | Xiang-Tao Chen, Peichun Sun, Qingyan Guo, Li Xu, Yi Xu, Hui-Li Wang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Endocrinology Diabetes and Metabolism Central nervous system S6 lcsh:TX341-641 Biology lcsh:Biochemistry 03 medical and health sciences 0302 clinical medicine Internal medicine medicine lcsh:QD415-436 Receptor Spine density PI3K/AKT/mTOR pathway Mtor signaling Nutrition and Dietetics Bitter melon Blot 030104 developmental biology Endocrinology medicine.anatomical_structure Hypothalamus mTOR Bitter melon seed oil Anti-obesity Phosphorylation lcsh:Nutrition. Foods and food supply 030217 neurology & neurosurgery Food Science |
| Zdroj: | Journal of Nutrition & Intermediary Metabolism, Vol 6, Iss C, Pp 16-21 (2016) |
| ISSN: | 2352-3859 |
| DOI: | 10.1016/j.jnim.2016.04.003 |
| Popis: | Bitter melon seed oil (BMSO) was found to have an advantageous effect on anti-obesity. Up to date, the mechanisms underlying this process have been extensively investigated. However, there are very few reports focusing on the roles of central nervous system (CNS) involved. In this study, Golgi-Cox staining and western blotting assays were used to examine the hypothalamic spine density and the expression levels of NMDA-2B receptor and P-S6 protein, respectively. A significant reduction concerning hypothalamic spine density was observed in HFD mice, a phenomenon that could be partially rescued by the BMSO administration. Furthermore, it was found that BMSO could also reverse the changes upon the phosphorylation levels of S6, a typical protein involved in mTOR signaling pathway, indicating that mTOR signaling potentially participated in this metabolism regulation. Besides, NMDA-2B levels were up-regulated in HFD mice, which could not be considerably influenced by BMSO. In summary, this study first proposed aberrant hypothalamic plasticity as CNS's roles in BMSO's fat-reducing effects, favoring the better recognition and treatment of the intractable hypothalamic obesity. |
| Databáze: | OpenAIRE |
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