Ginsenoside Rb1 ameliorates cisplatin-induced learning and memory impairments
| Autor: | Hongliang Xu, Yake Zheng, Chen Chen, Tianwen Wu, Yajun Lian, Haifeng Zhang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
memory impairment cisplatin Pharmacology medicine.disease_cause Biochemistry Genetics and Molecular Biology (miscellaneous) Neuroprotection 03 medical and health sciences 0302 clinical medicine lcsh:Botany ginsenoside Rb1 oxidative stress Medicine Memory impairment Cisplatin Panax ginseng root business.industry food and beverages eye diseases lcsh:QK1-989 030104 developmental biology nervous system Complementary and alternative medicine Ginsenoside Rb1 neuronal loss business 030217 neurology & neurosurgery Oxidative stress Research Article Biotechnology medicine.drug |
| Zdroj: | Journal of Ginseng Research Journal of Ginseng Research, Vol 43, Iss 4, Pp 499-507 (2019) |
| ISSN: | 1226-8453 |
| DOI: | 10.1016/j.jgr.2017.07.009 |
| Popis: | Background: Ginsenoside Rb1 (Rb1), a dominant component from the extract of Panax ginseng root, exhibits neuroprotective functions in many neurological diseases. This study was intended to investigate whether Rb1 can attenuate cisplatin-induced memory impairments and explore the potential mechanisms. Methods: Cisplatin was injected intraperitoneally with a dose of 5 mg/kg/wk, and Rb1 was administered in drinking water at the dose of 2 mg/kg/d to rats for 5 consecutive wk. The novel objects recognition task and Morris water maze were used to detect the memory of rats. Nissl staining was used to examine the neuron numbers in the hippocampus. The activities of superoxide dismutase, glutathione peroxidase, cholineacetyltransferase, acetylcholinesterase, and the levels of malondialdehyde, reactive oxygen species, acetylcholine, tumor necrosis factor-α, interleukin-1β, and interleukin-10 were measured by ELISA to assay the oxidative stress, cholinergic function, and neuroinflammation in the hippocampus. Results: Rb1 administration effectively ameliorates the memory impairments caused by cisplatin in both novel objects recognition task and Morris water maze task. Rb1 also attenuates the neuronal loss induced by cisplatin in the different regions (CA1, CA3, and dentate gyrus) of the hippocampus. Meanwhile, Rb1 is able to rescue the cholinergic neuron function, inhibit the oxidative stress and neuroinflammation in cisplatin-induced rat brain. Conclusion: Rb1 rescues the cisplatin-induced memory impairment via restoring the neuronal loss by reducing oxidative stress and neuroinflammation and recovering the cholinergic neuron functions. Keywords: cisplatin, ginsenoside Rb1, memory impairment, neuronal loss, oxidative stress |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|