The Effect of Vitamin A Supplementation on Biochemical Parameters in Multiple Sclerosis Patients
| Autor: | Sima Jafarirad, Ali Akbar Saboor-Yaraghi, Fereydoon Siassi, Sama Bitarafan, Reza Amani, Mohammad Hossein Harirchian |
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| Rok vydání: | 2013 |
| Předmět: |
Vitamin
Pathology medicine.medical_specialty Multiple Sclerosis Physiology chemistry.chemical_compound Immune system C-reactive Protein medicine High doses Vitamin A Adverse effect biology business.industry Multiple sclerosis fungi C-reactive protein food and beverages Cancer General Medicine medicine.disease Kowsar chemistry biology.protein business Research Article |
| Zdroj: | Iranian Red Crescent Medical Journal |
| ISSN: | 2074-1812 2074-1804 |
| DOI: | 10.5812/ircmj.3480 |
| Popis: | Background Vitamin A has different functions in the body and after being converted to acid form; it can play many roles in immune system regulation. Therefore, this vitamin can be used as a supplement in the treatment of diseases, such as cancer and autoimmune diseases. Vitamin A is a fat-soluble compound and its long-term consumption in high doses can have some adverse effects. Objective The current study aimed to investigate the possible complications and find solutions to minimize the adverse effects. Patients and Methods This study was a double blind randomized clinical trial. In the main study, vitamin A (as retinyl palmitate) was given to 35 multiple sclerosis (MS) patients in order to regulate their immune system with a dose of 25000 IU/day for a period of six months. To investigate the possible biochemical complications, lipid profiles, fasting blood sugar (FBS), liver enzymes, and C-reactive protein (CRP) were tested. Results Vitamin A did not have a significant difference in lipid profiles, FBS and liver enzymes between the two groups receiving vitamin A and the placebo, but CRP increased in patients who were taking vitamin A, 1.65±0.43 (mg/L) and 2.88±0.67, (Mean±SEM), before and after the intervention respectively (P=0.029), and statistical analysis showed significant differences with the group receiving placebo (P=0.011) and CRP level in vitamin A group was 1.3 mg/L more than those of the placebo group after intervention (P=0.011). Conclusions Considering that no significant difference was found in the proven vitamin A side effects, due to the increase in CRP, frequent clinical and biochemical controls are required along with vitamin A supplementation. |
| Databáze: | OpenAIRE |
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