Photodynamic therapy as a potential oral disinfection protocol during COVID-19 outbreak
| Autor: | Henrico Badaoui Strazzi-Sahyon, Gustavo Sivieri-Araujo, Luciano Tavares Ângelo Cintra, Paulo Henrique dos Santos, Larissa Pereira Nunes, Lucas Orbolato Chalub |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
2019-20 coronavirus outbreak
COVID-19 Vaccines Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) medicine.medical_treatment Pneumonia Viral Biophysics Photodynamic therapy Dermatology Betacoronavirus COVID-19 Testing Medicine Humans Pharmacology (medical) Saliva Letter to the Editor Pandemics Aged business.industry Clinical Laboratory Techniques SARS-CoV-2 Outbreak COVID-19 Photosensitizing Agent Middle Aged Viral Load Virology Oncology Female business Coronavirus Infections Viral load |
| Zdroj: | Photodiagnosis and Photodynamic Therapy |
| ISSN: | 1572-1000 |
| DOI: | 10.1016/j.pdpdt.2021.102187 |
| Popis: | Patients with coronavirus disease 2019 (COVID-19) can unknowingly spread the virus to several people during the early subclinical period.We evaluated the viral dynamics in various body fluid specimens, such as nasopharyngeal swab, oropharyngeal swab, saliva, sputum, and urine specimens, of two patients with COVID-19 from hospital day 1 to 9. Additional samples of the saliva were taken at 1 hour, 2 hours, and 4 hours after using a chlorhexidine mouthwash. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load was determined by real-time reverse transcriptase polymerase chain reaction (rRT-PCR).SARS-CoV-2 was detected from all the five specimens of both patients by rRT-PCR. The viral load was the highest in the nasopharynx (patient 1 = 8.41 logSARS-CoV-2 viral load was consistently high in the saliva; it was relatively higher than that in the oropharynx during the early stage of COVID-19. Chlorhexidine mouthwash was effective in reducing the SARS-CoV-2 viral load in the saliva for a short-term period. |
| Databáze: | OpenAIRE |
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